iPTMnet Report for O95243 (MBD4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95243 / MBD4_HUMAN
Protein Name Methyl-CpG-binding domain protein 4
Gene Name Name: MBD4
Synonyms:MED1;
Organism Homo sapiens (Human)

PRO ID PR:O95243
DAG View
PRO Name methyl-CpG-binding domain protein 4 (human)
Definition A methyl-CpG-binding domain protein 4 that is encoded in the genome of human.
Short Label hMBD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95243 (MBD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K36 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
T102 Phosphorylation IEDB 32387766
Y109 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K137 Sumoylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S165 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 19829383
K215 Sumoylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K232 Acetylation PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K239 Acetylation PhosphoSitePlus
K239 Sumoylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S262 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 19829383
K270 Sumoylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
C289 Methylation IEDB 31844290
S304 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S318 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S321 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K368 Sumoylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K377 Sumoylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus   UniProt 23186163
T439 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S318 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K391 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y109 C109 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K117 R117 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
K117 T117 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S253 R253 Biomuta DOID:363 / uterine cancer [ icgc ]
S308 N308 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S316 L316 Biomuta DOID:4159 / skin cancer [ cosmic ]
S316 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K335 R335 Biomuta DOID:363 / uterine cancer [ icgc ]
T439 A439 Biomuta DOID:363 / uterine cancer [ icgc ]
K484 M484 Biomuta DOID:1324 / lung cancer [ cosmic ]
K518 N518 Biomuta DOID:4159 / skin cancer [ cosmic ]