iPTMnet Report for O95239 (KIF4A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95239 / KIF4A_HUMAN
Protein Name Chromosome-associated kinesin KIF4A
Gene Name Name: KIF4A
Synonyms:KIF4;
Organism Homo sapiens (Human)

PRO ID PR:O95239
DAG View
PRO Name chromosome-associated kinesin KIF4A (human)
Definition A chromosome-associated kinesin KIF4A that is encoded in the genome of human.
Short Label hKIF4A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95239 (KIF4A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K129 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K281 Acetylation PhosphoSitePlus
K282 Acetylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus
S394 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K401 Sumoylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K460 Sumoylation PhosphoSitePlus
S507 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
S508 Phosphorylation PhosphoSitePlus
K542 Sumoylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
T544 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K593 Acetylation PhosphoSitePlus
K624 Acetylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
Y684 Phosphorylation PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K772 Sumoylation PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
T799 Phosphorylation Q96GD4 (AURKB) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 25512391, ...30576375, 23940115, 18669648, 32195664, 20068231
S801 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28992084, 23186163, 17081983, ...16565220, 18669648, 20068231, 16964243
S810 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983, 16565220
S812 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S815 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T817 Phosphorylation phospho.ELM 18669648, 17081983
K840 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
K868 Acetylation PhosphoSitePlus
Y869 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
T893 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
S941 Phosphorylation PhosphoSitePlus
K946 Ubiquitination PhosphoSitePlus
S951 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220
S953 Phosphorylation PhosphoSitePlus
K955 Ubiquitination PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
K964 Ubiquitination PhosphoSitePlus
K993 Ubiquitination PhosphoSitePlus
T995 Phosphorylation PhosphoSitePlus   UniProt 18318008
S1001 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 30576375, 18669648, 20068231, ...18318008
T1010 Phosphorylation phospho.ELM 17081983
S1013 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 16565220
S1016 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S1017 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220
Y1020 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1028 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1038 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220, 17081983, 18220336
S1048 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1051 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K1071 Sumoylation PhosphoSitePlus
K1095 Ubiquitination PhosphoSitePlus
T1115 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16565220
T1133 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1136 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1139 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1146 Phosphorylation PhosphoSitePlus
T1149 Phosphorylation PhosphoSitePlus
T1161 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 29771379, 18669648, 16565220
S1164 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
T1181 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 16964243, 30576375, ...16565220, 18669648, 20068231
S1186 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 30576375, 18669648, 20068231, ...16565220
Y1200 Phosphorylation PhosphoSitePlus
S1216 Phosphorylation PhosphoSitePlus
S1219 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1222 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16565220, 17081983, ...18220336
Site PTM Type PTM Enzyme Score Source PMID
Y288 Phosphorylation HPRD 20068231
T294 Phosphorylation HPRD 20068231
S394 Phosphorylation HPRD 19651622, 17081983, 20068231, ...19007248
T474 Phosphorylation HPRD 17081983
T490 Phosphorylation HPRD 17081983
S501 Phosphorylation HPRD 19007248
S507 Phosphorylation HPRD 19691289, 16565220
S508 Phosphorylation HPRD 19691289
T544 Phosphorylation HPRD 19651622, 17081983
T799 Phosphorylation HPRD 18669648, 17081983, 20068231, ...19691289
S801 Phosphorylation HPRD 19413330, 18212344, 20058876, ...19664994, 19691289, 16565220, 18669648, 20068231, 16964243
S810 Phosphorylation HPRD 16565220, 19691289, 19007248
S812 Phosphorylation HPRD 18669648
S815 Phosphorylation HPRD 17081983, 19691289, 18452278, ...19651622, 19007248, 20068231
T817 Phosphorylation HPRD 18669648, 17081983
Y869 Phosphorylation HPRD 20068231
S876 Phosphorylation HPRD 20068231
S877 Phosphorylation HPRD 20068231
S951 Phosphorylation HPRD 18669648, 19691289, 20068231, ...16565220
S1001 Phosphorylation HPRD 18669648, 20068231
T1010 Phosphorylation HPRD 17081983
S1013 Phosphorylation HPRD 18669648, 16565220
S1016 Phosphorylation HPRD 18669648, 17081983
S1017 Phosphorylation HPRD 18669648, 16565220
Y1020 Phosphorylation HPRD 18669648
S1028 Phosphorylation HPRD 18669648
S1038 Phosphorylation HPRD 20068231, 16565220
Y1046 Phosphorylation HPRD 17081983
S1048 Phosphorylation HPRD 17081983
S1051 Phosphorylation HPRD 17081983
S1126 Phosphorylation HPRD 16565220, 19691289, 20068231, ...19007248
T1129 Phosphorylation HPRD 19007248
T1133 Phosphorylation HPRD 18669648, 18452278
S1136 Phosphorylation HPRD 18669648, 18452278
S1139 Phosphorylation HPRD 18669648, 18452278
T1161 Phosphorylation HPRD 19413330, 18669648, 16565220
T1181 Phosphorylation HPRD 19651622, 18669648, 16964243, ...20068231, 16565220
S1186 Phosphorylation HPRD 19651622, 18669648, 20068231, ...16565220
S1219 Phosphorylation HPRD 18669648
S1222 Phosphorylation HPRD 18452278
S1225 Phosphorylation HPRD 19413330, 18669648, 16565220, ...20068231, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T203 A203 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K292 T292 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S394 F394 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T423 I423 Biomuta DOID:4159 / skin cancer [ cosmic ]
K444 T444 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T490 S490 Biomuta DOID:4159 / skin cancer [ cosmic ]
K676 Q676 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K715 R715 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S801 F801 Biomuta DOID:4159 / skin cancer [ cosmic ]
S810 L810 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic, icgc ]
S876 F876 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K946 R946 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K993 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1017 Y1017 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
S1139 F1139 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1186 F1186 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1225 Y1225 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]