iPTMnet Report for O95238 (SPDEF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95238 / SPDEF_HUMAN
Protein Name SAM pointed domain-containing Ets transcription factor
Gene Name Name: SPDEF
Synonyms:PDEF,PSE;
Organism Homo sapiens (Human)

PRO ID PR:O95238
DAG View
PRO Name SAM pointed domain-containing Ets transcription factor (human)
Definition A SAM pointed domain-containing Ets transcription factor that is encoded in the genome of human.
Short Label hSPDEF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95238 (SPDEF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T50 Phosphorylation RLIMS-P 20550708
S238 Phosphorylation PhosphoSitePlus   Signor 26885618
S238 Phosphorylation Q9UQ88 (CDK11A) PhosphoSitePlus   Signor 26885618
S242 Phosphorylation PhosphoSitePlus   Signor 26885618
S242 Phosphorylation Q9UQ88 (CDK11A) PhosphoSitePlus   Signor 26885618
S243 Phosphorylation PhosphoSitePlus   Signor 26885618
S243 Phosphorylation Q9UQ88 (CDK11A) PhosphoSitePlus   Signor 26885618
S264 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
Y329 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T50 M50 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S243 L243 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S264 R264 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y265 C265 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]