iPTMnet Report for O95218 (ZRANB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95218 / ZRAB2_HUMAN
Protein Name Zinc finger Ran-binding domain-containing protein 2
Gene Name Name: ZRANB2
Synonyms:ZIS,ZNF265;
Organism Homo sapiens (Human)

PRO ID PR:O95218
DAG View
PRO Name zinc finger Ran-binding domain-containing protein 2 (human)
Definition A zinc finger Ran-binding domain-containing protein 2 that is encoded in the genome of human.
Short Label hZRANB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95218 (ZRANB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T50 Phosphorylation PhosphoSitePlus
K54 Acetylation PhosphoSitePlus   UniProt 19608861
K54 Ubiquitination PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
R61 Methylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
T90 Phosphorylation PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K95 Sumoylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S120 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18318008, 18669648, 24275569, 19690332, 20068231
Y124 Phosphorylation PhosphoSitePlus
K137 Methylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S153 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 18669648, 20068231
S165 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 17287340, 20068231
K182 Ubiquitination PhosphoSitePlus
Y183 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S188 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...15302935, 18669648, 23186163, 19690332, 20068231
S193 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S206 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
T303 Phosphorylation phospho.ELM   UniProt 18669648, 21406692
S305 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 21406692, 18669648, ...19690332, 20068231
S307 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 21406692, 18669648, ...19690332, 20068231
R310 Phosphorylation UniProt 17525332, 18669648, 20068231
S318 Phosphorylation phospho.ELM 18669648
S323 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 18669648, 20068231
Y114 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S120 Phosphorylation HPRD 17322306, 18212344, 20230923, ...19562805, 19664994, 19664995, 19007248, 19651622, 18669648, 18707149, 20166139, 18452278, 19415658, 20068231
Y124 Phosphorylation HPRD 17081983, 20068231
S153 Phosphorylation HPRD 17081983, 18767875, 18452278, ...19651622, 18669648, 20166139, 19415658, 20068231
S181 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983, 20068231
Y183 Phosphorylation HPRD 18669648
S188 Phosphorylation O95218 (ZRANB2) HPRD 19413330, 17287340, 18767875, ...15302935, 18452278, 19651622, 19664994, 18669648, 20166139, 20068231
S193 Phosphorylation HPRD 19413330, 20166139, 17081983, ...20068231, 18452278
S245 Phosphorylation HPRD 19651622
S249 Phosphorylation HPRD 19651622
S275 Phosphorylation HPRD 19651622
S276 Phosphorylation HPRD 19651622
S277 Phosphorylation HPRD 19651622
S278 Phosphorylation HPRD 19651622
S279 Phosphorylation HPRD 19651622
S280 Phosphorylation HPRD 19651622, 15302935
S305 Phosphorylation HPRD 20068231
S307 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
Y114 Phosphorylation HPRD   phospho.ELM 18669648, 17081983, 20068231, ...18452278
S120 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17322306, 18212344, 20230923, ...19562805, 18220336, 19664994, 19664995, 19007248, 19651622, 18669648, 18707149, 20166139, 18452278, 19415658, 20068231
Y124 Phosphorylation HPRD 17081983, 20068231
S153 Phosphorylation HPRD   phospho.ELM 17081983, 18767875, 18452278, ...19651622, 18669648, 20166139, 19415658, 20068231
S181 Phosphorylation HPRD   phospho.ELM 19651622, 18669648, 17287340, ...17081983, 20068231
Y183 Phosphorylation HPRD   phospho.ELM 18669648
S188 Phosphorylation O95218 (ZRANB2) HPRD   phospho.ELM 19413330, 17287340, 18767875, ...15302935, 18452278, 19651622, 19664994, 18669648, 20166139, 20068231
S193 Phosphorylation HPRD 19413330, 20166139, 17081983, ...20068231, 18452278
S206 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S245 Phosphorylation HPRD 19651622
S249 Phosphorylation HPRD 19651622
S275 Phosphorylation HPRD 19651622
S276 Phosphorylation HPRD 19651622
S277 Phosphorylation HPRD 19651622
S278 Phosphorylation HPRD 19651622
S279 Phosphorylation HPRD 19651622
S280 Phosphorylation HPRD 19651622, 15302935
T303 Phosphorylation HPRD   PhosphoSitePlus 17287340, 17081983, 19651622, ...18669648, 20068231
S305 Phosphorylation HPRD   PhosphoSitePlus 17525332, 17287340, 18212344, ...19664994, 19651622, 18669648, 20166139, 20068231
S307 Phosphorylation HPRD   PhosphoSitePlus 17525332, 17287340, 18212344, ...19664994, 19651622, 18669648, 20166139, 19415658, 20068231
S310 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 19651622, 18669648, ...19415658, 20068231
T317 Phosphorylation PhosphoSitePlus


O95218 (ZRANB2) as PTM Enzyme



Substrate Site Score Source PMID
O95218-2 (ZRANB2) S188 HPRD 19413330, 17287340, 18767875, ...15302935, 18452278, 19651622, 19664994, 18669648, 20166139, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S83 * Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S188 T188 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S208 F208 Biomuta DOID:4159 / skin cancer [ cosmic ]
S218 P218 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S249 L249 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S305 L305 Biomuta DOID:4159 / skin cancer [ cosmic ]
S323 Y323 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S326 I326 Biomuta DOID:9256 / colorectal cancer [ cosmic ]