Protein Information

Cytoscape View


UniProt AC / UniProt ID O95202 / LETM1_HUMAN
Protein Name Mitochondrial proton/calcium exchanger protein precursor
Gene Name Name: LETM1
Organism Homo sapiens (Human)

PRO ID PR:O95202
DAG View
PRO Name mitochondrial proton/calcium exchanger protein (human)
Definition A mitochondrial proton/calcium exchanger protein that is encoded in the genome of human.
Short Label hLETM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95202 (LETM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus   RLIMS-P 29123128
K252 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K284 Acetylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
R307 Methylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
R393 Methylation PhosphoSitePlus
Y579 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
K597 Acetylation PhosphoSitePlus   UniProt 19608861
S602 Phosphorylation PhosphoSitePlus
T643 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S142 Phosphorylation HPRD 20068231
T175 Phosphorylation HPRD 20068231
T239 Phosphorylation HPRD 20068231
T426 Phosphorylation HPRD 20068231
S428 Phosphorylation HPRD 20068231
S435 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T239 K239 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S287 Y287 Biomuta DOID:363 / uterine cancer [ tcga ]
R307 C307 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R307 L307 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K373 N373 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T426 N426 Biomuta DOID:3571 / liver cancer [ icgc ]
S580 R580 Biomuta DOID:3070 / malignant glioma [ cosmic ]