iPTMnet Report for O95202 (LETM1)
Protein Information
| UniProt AC / UniProt ID | O95202 / LETM1_HUMAN |
| Protein Name | Mitochondrial proton/calcium exchanger protein precursor |
| Gene Name | Name: LETM1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O95202 |
| PRO Name | mitochondrial proton/calcium exchanger protein (human) |
| Definition | A mitochondrial proton/calcium exchanger protein that is encoded in the genome of human. |
| Short Label | hLETM1 |
| Category | organism-gene |
O95202 (LETM1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S3 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S8 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S126 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y141 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S142 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y164 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T175 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S190 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T192 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 29123128 | ||
| K252 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K257 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K284 | Acetylation | score1 | PhosphoSitePlus | |||
| S287 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K292 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R307 | Methylation | score1 | PhosphoSitePlus | |||
| K373 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R393 | Methylation | score1 | PhosphoSitePlus | |||
| C552 | Methylation | score1 | IEDB | 31844290 | ||
| Y579 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S580 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K597 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| S602 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T643 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S649 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S666 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K682 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S739 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T239 | K239 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K252 | N252 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S287 | Y287 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| R307 | C307 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| R307 | L307 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K373 | N373 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S580 | R580 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] |
DAG View