iPTMnet Report for O95198 (KLHL2)
Protein Information
| UniProt AC / UniProt ID | O95198 / KLHL2_HUMAN |
| Protein Name | Kelch-like protein 2 |
| Gene Name | Name: KLHL2 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O95198 |
| PRO Name | kelch-like protein 2 (human) |
| Definition | A kelch-like protein 2 that is encoded in the genome of human. |
| Short Label | hKLHL2 |
| Category | organism-gene |
DAG ViewO95198 (KLHL2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S90 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T122 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C170 | Methylation | score1 | IEDB | 31844290 | ||
| T301 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K329 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y455 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K511 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q96RU2 (USP28) | S67 | O95198 (KLHL2) | inhibited_association | eFIP | 31938050 | |
| Phosphorylation | Q9HA47 (UCK1) | S145 | O95198 (KLHL2) | unknown | eFIP | 31938050 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T301 | I301 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y455 | F455 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
