iPTMnet Report for O95197 (RTN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95197 / RTN3_HUMAN
Protein Name Reticulon-3
Gene Name Name: RTN3
Synonyms:ASYIP,NSPL2;
Organism Homo sapiens (Human)

PRO ID PR:O95197
DAG View
PRO Name reticulon-3 (human)
Definition A reticulon-3 that is encoded in the genome of human.
Short Label hRTN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95197 (RTN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 21406692, 22223895, ...20068231
T8 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
S30 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S110 Phosphorylation PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus   UniProt 23186163
S231 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus   UniProt 23186163
S268 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus   UniProt 23186163
T318 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus
S391 O-Glycosylation GlyGen 29351928, 35083852, 33465208, ...28657654
S395 Phosphorylation PhosphoSitePlus
T396 O-Glycosylation GlyGen 29351928, 35083852, 33465208, ...28657654
T396 Phosphorylation PhosphoSitePlus
T399 O-Glycosylation GlyGen 29351928, 35083852, 33465208, ...28657654
K419 Ubiquitination PhosphoSitePlus
K434 Acetylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus   UniProt 23186163
T467 Phosphorylation PhosphoSitePlus
S526 O-Glycosylation GlyGen 29351928, 35083852, 33465208, ...28657654
K540 Methylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
T614 Phosphorylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S649 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S650 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S678 O-Glycosylation GlyGen 29351928, 35083852, 33465208, ...28657654
T687 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
R754 Methylation PhosphoSitePlus
T811 Phosphorylation PhosphoSitePlus
D956 Methylation IEDB 29786170
Y969 Phosphorylation PhosphoSitePlus
K998 Ubiquitination PhosphoSitePlus
Y1004 Phosphorylation PhosphoSitePlus
K1013 Acetylation PhosphoSitePlus
K1013 Ubiquitination PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
K1022 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 18491316
S23 Phosphorylation HPRD 20068231
S30 Phosphorylation HPRD 19413330, 18578522, 17081983, ...20068231
T39 Phosphorylation HPRD 20068231
S210 Phosphorylation HPRD 19413330
S227 Phosphorylation HPRD 19651622, 18578522
S541 Phosphorylation HPRD 17081983
S630 Phosphorylation HPRD 18669648
S631 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 18491316
S23 Phosphorylation HPRD 20068231
S30 Phosphorylation HPRD 19413330, 18578522, 17081983, ...20068231
T39 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 18491316
S23 Phosphorylation HPRD 20068231
S30 Phosphorylation HPRD 19413330, 18578522, 17081983, ...20068231
T39 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 18491316
S23 Phosphorylation HPRD 20068231
S30 Phosphorylation HPRD 19413330, 18578522, 17081983, ...20068231
T39 Phosphorylation HPRD 20068231
K206 Ubiquitination PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K152 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K206 R206 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S234 L234 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S243 F243 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S316 L316 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S391 Y391 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S541 N541 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S560 N560 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S616 F616 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S631 F631 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S650 F650 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
D956 E956 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
D956 H956 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1022 E1022 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]