iPTMnet Report for O95154 (AKR7A3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95154 / ARK73_HUMAN
Protein Name Aflatoxin B1 aldehyde reductase member 3
Gene Name Name: AKR7A3
Synonyms:AFAR2;
Organism Homo sapiens (Human)

PRO ID PR:O95154
DAG View
PRO Name aflatoxin B1 aldehyde reductase member 3 (human)
Definition An aflatoxin B1 aldehyde reductase member 3 that is encoded in the genome of human.
Short Label hAKR7A3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95154 (AKR7A3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
T12 Phosphorylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
T27 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
S85 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 24275569
S90 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y111 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus   UniProt 24275569
S259 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R21 H21 Biomuta DOID:363 / uterine cancer [ icgc ]
T32 M32 Biomuta DOID:4159 / skin cancer [ cosmic ]
S143 F143 Biomuta DOID:4159 / skin cancer [ cosmic ]
T227 S227 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S259 I259 Biomuta DOID:363 / uterine cancer [ icgc ]