iPTMnet Report for O95140 (MFN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95140 / MFN2_HUMAN
Protein Name Mitofusin-2
Gene Name Name: MFN2
Synonyms:CPRP1,KIAA0214;
Organism Homo sapiens (Human)

PRO ID PR:O95140
DAG View
PRO Name mitofusin-2 (human)
Definition A mitofusin-2 that is encoded in the genome of human.
Short Label hMFN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95140 (MFN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S10 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus   Signor 22748923
S27 Phosphorylation P45984-2 (MAPK9) PhosphoSitePlus   Signor 22748923
K30 Ubiquitination PhosphoSitePlus
K36 Acetylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 31664033, 23620051, 29676259
K154 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
C188 Methylation IEDB 31844290
K192 Ubiquitination PhosphoSitePlus
S200 Phosphorylation RLIMS-P 30887444
K243 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K355 Acetylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23620051, 29676259
K460 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T70 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048377 (hMFN2/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K79 R79 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S378 F378 Biomuta DOID:4159 / skin cancer [ cosmic ]
K420 E420 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T423 M423 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T423 A423 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K463 N463 Biomuta DOID:3571 / liver cancer [ cosmic ]
K720 I720 Biomuta DOID:1324 / lung cancer [ cosmic ]
K720 T720 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K730 T730 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]