iPTMnet Report for O95096 (NKX2-2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95096 / NKX22_HUMAN
Protein Name Homeobox protein Nkx-2.2
Gene Name Name: NKX2-2
Synonyms:NKX2.2,NKX2B;
Organism Homo sapiens (Human)

PRO ID PR:O95096
DAG View
PRO Name homeobox protein Nkx-2.2 (human)
Definition A homeobox protein Nkx-2.2 that is encoded in the genome of human.
Short Label hNKX2-2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95096 (NKX2-2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T6 R6 Biomuta DOID:1324 / lung cancer [ cosmic ]
T8 M8 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic ]
T8 A8 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S11 L11 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S58 R58 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S58 N58 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]