Protein Information

Cytoscape View


UniProt AC / UniProt ID O95071 / UBR5_HUMAN
Protein Name E3 ubiquitin-protein ligase UBR5
Gene Name Name: UBR5
Synonyms:EDD,EDD1,HYD,KIAA0896;
Organism Homo sapiens (Human)

PRO ID PR:O95071
DAG View
PRO Name E3 ubiquitin-protein ligase UBR5 (human)
Definition An E3 ubiquitin-protein ligase UBR5 that is encoded in the genome of human.
Short Label hUBR5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95071 (UBR5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 19413330
K28 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
R78 Methylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S110 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 23186163, ...21924388
T119 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S139 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S143 Phosphorylation PhosphoSitePlus
R146 Methylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
R167 Methylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S174 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S191 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
K200 Ubiquitination PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S327 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 21924388, ...16565220, 22067460, 18669648
K337 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus   UniProt 21924388
K366 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus   UniProt 21924388, 23186163
K583 Ubiquitination PhosphoSitePlus
S598 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
T605 Phosphorylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus   UniProt 21924388, 23186163
S615 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21924388, 28559278
K663 Acetylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
T734 Phosphorylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus   UniProt 21924388, 23186163
S928 Phosphorylation PhosphoSitePlus   UniProt 21924388
S967 Phosphorylation PhosphoSitePlus
S971 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R977 Methylation PhosphoSitePlus
R984 Methylation PhosphoSitePlus
S985 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus
R997 Methylation PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus   UniProt 21924388
K1109 Ubiquitination PhosphoSitePlus
T1115 Phosphorylation PhosphoSitePlus   UniProt 21924388
T1135 Phosphorylation PhosphoSitePlus   UniProt 21924388
K1141 Ubiquitination PhosphoSitePlus
S1227 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21924388, 28559278
K1248 Ubiquitination PhosphoSitePlus
K1305 Ubiquitination PhosphoSitePlus
T1306 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1308 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21924388, 18669648, 23186163
S1312 Phosphorylation PhosphoSitePlus
K1340 Ubiquitination PhosphoSitePlus
S1347 Phosphorylation PhosphoSitePlus
K1351 Ubiquitination PhosphoSitePlus
S1355 Phosphorylation PhosphoSitePlus   UniProt 21924388
S1375 Phosphorylation PhosphoSitePlus   UniProt 21924388
S1481 Phosphorylation PhosphoSitePlus   UniProt 21924388
S1532 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S1549 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 22067460, 18669648, 24275569, 20068231
S1551 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1610 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1679 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S1728 Phosphorylation PhosphoSitePlus
T1729 Phosphorylation PhosphoSitePlus
S1732 Phosphorylation PhosphoSitePlus
T1736 Phosphorylation PhosphoSitePlus   UniProt 21924388
S1740 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1741 Phosphorylation PhosphoSitePlus   UniProt 21924388
Y1746 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18669648
T1760 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1761 Phosphorylation phospho.ELM 18669648
S1780 Phosphorylation PhosphoSitePlus   UniProt 21924388
S1782 Phosphorylation PhosphoSitePlus
S1789 Phosphorylation PhosphoSitePlus
S1875 Phosphorylation PhosphoSitePlus
S1878 Phosphorylation PhosphoSitePlus
T1902 Phosphorylation PhosphoSitePlus
S1905 Phosphorylation PhosphoSitePlus
R1914 Methylation PhosphoSitePlus
T1965 Phosphorylation PhosphoSitePlus
T1966 Phosphorylation PhosphoSitePlus
T1969 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 21924388, ...22067460, 18669648, 20068231
S1990 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1998 Phosphorylation PhosphoSitePlus
S2001 Phosphorylation PhosphoSitePlus
S2011 Phosphorylation PhosphoSitePlus
S2026 Phosphorylation PhosphoSitePlus   UniProt 21924388
S2028 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 21924388
T2030 Phosphorylation PhosphoSitePlus   UniProt 21924388
K2063 Ubiquitination PhosphoSitePlus
S2071 Phosphorylation PhosphoSitePlus
Y2075 Phosphorylation PhosphoSitePlus
S2076 Phosphorylation PhosphoSitePlus   UniProt 21924388
K2101 Ubiquitination PhosphoSitePlus
S2103 Phosphorylation PhosphoSitePlus
K2136 Ubiquitination PhosphoSitePlus
S2140 Phosphorylation PhosphoSitePlus
R2190 Methylation PhosphoSitePlus
T2213 Phosphorylation PhosphoSitePlus   UniProt 21924388
K2221 Ubiquitination PhosphoSitePlus
S2241 Phosphorylation PhosphoSitePlus   UniProt 23186163
T2270 Phosphorylation PhosphoSitePlus
K2282 Ubiquitination PhosphoSitePlus
S2289 Phosphorylation PhosphoSitePlus   UniProt 21924388
K2320 Ubiquitination PhosphoSitePlus
S2325 Phosphorylation PhosphoSitePlus
R2353 Methylation PhosphoSitePlus
S2369 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S2379 Phosphorylation PhosphoSitePlus
S2434 Phosphorylation PhosphoSitePlus
S2437 Phosphorylation PhosphoSitePlus
S2460 Phosphorylation PhosphoSitePlus
S2469 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2470 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K2472 Ubiquitination PhosphoSitePlus
S2483 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 28559278
S2484 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21924388, 18669648
S2486 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
T2495 Phosphorylation PhosphoSitePlus
K2510 Ubiquitination PhosphoSitePlus
S2586 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
K2656 Ubiquitination PhosphoSitePlus
S2779 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T107 Phosphorylation HPRD 18691976
S110 Phosphorylation HPRD 18669648
S139 Phosphorylation HPRD 18691976, 18669648, 20068231
S286 Phosphorylation HPRD 18691976, 20068231
S287 Phosphorylation HPRD 16083285, 20068231
S327 Phosphorylation HPRD 18669648, 20068231, 16565220
S598 Phosphorylation HPRD 18088087
T605 Phosphorylation HPRD 18491316
S612 Phosphorylation HPRD 18491316
S615 Phosphorylation HPRD 18491316
S625 Phosphorylation HPRD 18491316
S971 Phosphorylation HPRD 18669648
S1018 Phosphorylation HPRD 20068231
T1306 Phosphorylation HPRD 18669648
S1308 Phosphorylation HPRD 18669648, 20068231
S1549 Phosphorylation HPRD 19664995, 18691976, 17081983, ...18767875, 18077418, 19007248, 19691289, 19651622, 18669648, 20166139, 20068231, 17924679
S1551 Phosphorylation HPRD 19651622, 19007248
S1733 Phosphorylation HPRD 20068231
T1734 Phosphorylation HPRD 20068231
S1735 Phosphorylation HPRD 20068231
S1740 Phosphorylation HPRD 18669648
Y1746 Phosphorylation HPRD 15592455, 18669648
T1760 Phosphorylation HPRD 18669648
S1761 Phosphorylation HPRD 18669648
T1965 Phosphorylation HPRD 18491316
T1969 Phosphorylation HPRD 18691976, 18669648, 18491316, ...20068231
S2011 Phosphorylation HPRD 19651622
S2026 Phosphorylation HPRD 17081983
S2028 Phosphorylation HPRD 17081983, 20068231
S2071 Phosphorylation HPRD 17525332
S2241 Phosphorylation HPRD 19691289
S2424 Phosphorylation HPRD 17081983
S2434 Phosphorylation HPRD 17081983
S2437 Phosphorylation HPRD 17081983
S2470 Phosphorylation HPRD 18669648
S2483 Phosphorylation HPRD 18669648
S2484 Phosphorylation HPRD 18669648
S2486 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35222 (CTNNB1) S37 O95071 (UBR5) unknown eFIP 21118991


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T119 N119 Biomuta DOID:3571 / liver cancer [ icgc ]
S139 I139 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S154 P154 Biomuta DOID:4159 / skin cancer [ icgc ]
R167 Q167 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S191 L191 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
S286 * Biomuta DOID:3571 / liver cancer [ icgc ]
K346 R346 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K346 N346 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K663 N663 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K672 N672 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K761 N761 Biomuta DOID:1324 / lung cancer [ cosmic ]
S967 L967 Biomuta DOID:4362 / cervical cancer [ tcga ]
R977 W977 Biomuta DOID:363 / uterine cancer [ tcga ]
R977 Q977 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R984 Q984 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S995 P995 Biomuta DOID:3070 / malignant glioma [ tcga ]
S995 L995 Biomuta DOID:1612 / breast cancer [ icgc ]
T1115 P1115 Biomuta DOID:10534 / stomach cancer [ icgc, tcga ]
T1306 K1306 Biomuta DOID:3571 / liver cancer [ icgc ]
S1347 L1347 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1728 I1728 Biomuta DOID:1324 / lung cancer [ tcga ]
T1729 K1729 Biomuta DOID:3571 / liver cancer [ icgc ]
S1735 C1735 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
Y1746 F1746 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T1760 A1760 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1780 Y1780 Biomuta DOID:3571 / liver cancer [ icgc ]
S1875 F1875 Biomuta DOID:1612 / breast cancer [ tcga ]
T1902 N1902 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1905 R1905 Biomuta DOID:1324 / lung cancer [ tcga ]
R1914 Q1914 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T1998 A1998 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S2103 Y2103 Biomuta DOID:363 / uterine cancer [ tcga ]
S2140 Y2140 Biomuta DOID:3571 / liver cancer [ icgc ]
S2140 F2140 Biomuta DOID:1612 / breast cancer [ tcga ]
R2190 H2190 Biomuta DOID:1319 / brain cancer [ icgc ]
R2190 C2190 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K2221 N2221 Biomuta DOID:1324 / lung cancer [ tcga ]
R2353 Q2353 Biomuta DOID:1909 / melanoma [ cosmic ]
S2437 Y2437 Biomuta DOID:363 / uterine cancer [ tcga ]
S2460 N2460 Biomuta DOID:1324 / lung cancer [ cosmic ]
T2495 I2495 Biomuta DOID:9256 / colorectal cancer [ tcga ]