iPTMnet Report for O95069 (KCNK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95069 / KCNK2_HUMAN
Protein Name Potassium channel subfamily K member 2
Gene Name Name: KCNK2
Synonyms:TREK,TREK1;
Organism Homo sapiens (Human)

PRO ID PR:O95069
DAG View
PRO Name potassium channel subfamily K member 2 (human)
Definition A potassium channel subfamily K member 2 that is encoded in the genome of human.
Short Label hKCNK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95069 (KCNK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19622790, 11319556
S366 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S315 Phosphorylation HPRD 16006563
S348 Phosphorylation HPRD 11319549, 16006563
Site PTM Type PTM Enzyme Score Source PMID
S300 Phosphorylation HPRD   PhosphoSitePlus 16006563
S333 Phosphorylation HPRD   PhosphoSitePlus 11319549, 16006563
Site PTM Type PTM Enzyme Score Source PMID
Y11 Phosphorylation PhosphoSitePlus
S311 Phosphorylation HPRD 16006563
S344 Phosphorylation HPRD 11319549, 16006563


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S333 I333 Biomuta DOID:3571 / liver cancer [ cosmic ]
S344 I344 Biomuta DOID:3571 / liver cancer [ cosmic ]
S348 I348 Biomuta DOID:3571 / liver cancer [ cosmic ]
S366 L366 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S385 L385 Biomuta DOID:4159 / skin cancer [ cosmic ]