iPTMnet Report for O95049 (TJP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95049 / ZO3_HUMAN
Protein Name Tight junction protein ZO-3
Gene Name Name: TJP3
Synonyms:ZO3;
Organism Homo sapiens (Human)

PRO ID PR:O95049
DAG View
PRO Name tight junction protein ZO-3 (human)
Definition A tight junction protein ZO-3 that is encoded in the genome of human.
Short Label hTJP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95049 (TJP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y130 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus   UniProt 24275569
S138 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S164 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
S169 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus   UniProt 23186163
S212 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus   UniProt 24275569
S323 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus   UniProt 24275569
S327 Phosphorylation PhosphoSitePlus   UniProt 24275569
S331 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
R352 Methylation PhosphoSitePlus
R357 Methylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S369 O-Glycosylation GlyGen 30725225, 28580691
S369 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus   UniProt 24275569
S378 Phosphorylation PhosphoSitePlus
Y479 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
R518 Methylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T599 Phosphorylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
T679 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
Y725 Phosphorylation PhosphoSitePlus
S778 Phosphorylation PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus   UniProt 23186163
S864 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
S906 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231, 24275569


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S112 L112 Biomuta DOID:1324 / lung cancer [ cosmic ]
S135 F135 Biomuta DOID:4159 / skin cancer [ cosmic ]
S138 Y138 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S164 N164 Biomuta DOID:4362 / cervical cancer [ icgc ]
S203 N203 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S212 I212 Biomuta DOID:1324 / lung cancer [ cosmic ]
S222 P222 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S222 L222 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S323 C323 Biomuta DOID:4159 / skin cancer [ cosmic ]
S323 I323 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R352 W352 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
R352 Q352 Biomuta DOID:363 / uterine cancer [ icgc ]
S360 C360 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y361 C361 Biomuta DOID:3571 / liver cancer [ cosmic ]
S368 N368 Biomuta DOID:363 / uterine cancer [ icgc ]
S371 I371 Biomuta DOID:363 / uterine cancer [ icgc ]
Y479 F479 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R518 Q518 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S654 N654 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S778 F778 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S856 R856 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S864 L864 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S864 * Biomuta [ cosmic ]
S884 N884 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S905 F905 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]