iPTMnet Report for O94989 (ARHGEF15)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94989 / ARHGF_HUMAN
Protein Name Rho guanine nucleotide exchange factor 15
Gene Name Name: ARHGEF15
Synonyms:KIAA0915;
Organism Homo sapiens (Human)

PRO ID PR:O94989
DAG View
PRO Name Rho guanine nucleotide exchange factor 15 (human)
Definition A Rho guanine nucleotide exchange factor 15 that is encoded in the genome of human.
Short Label hARHGEF15
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94989 (ARHGEF15) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S33 Phosphorylation PhosphoSitePlus
S107 Phosphorylation RLIMS-P 30485813
S109 Phosphorylation PhosphoSitePlus   RLIMS-P 30485813
Y231 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
Y353 Phosphorylation neXtProt   PhosphoSitePlus   Signor 21029865
Y353 Phosphorylation P29323 (EPHB2) neXtProt   Signor 21029865
T394 Phosphorylation PhosphoSitePlus
T427 Phosphorylation PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
T835 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S33 Y33 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S33 F33 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]
S107 F107 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S109 F109 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S242 F242 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S435 F435 Biomuta [ cosmic ]
S776 N776 Biomuta DOID:1319 / brain cancer [ cosmic ]
S833 L833 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]