iPTMnet Report for O94979 (SEC31A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94979 / SC31A_HUMAN
Protein Name Protein transport protein Sec31A
Gene Name Name: SEC31A
Synonyms:KIAA0905,SEC31L1;ORFNames:HSPC275,HSPC334;
Organism Homo sapiens (Human)

PRO ID PR:O94979
DAG View
PRO Name protein transport protein Sec31A (human)
Definition A protein transport protein Sec31A that is encoded in the genome of human.
Short Label hSEC31A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94979 (SEC31A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C60 S-Nitrosylation dbSNO 19483679
Y101 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S269 O-Glycosylation GlyGen 29161034
S278 O-Glycosylation GlyGen 29161034
S323 Phosphorylation PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
R411 Methylation PhosphoSitePlus
S451 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
K460 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
K471 Methylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
R486 Methylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
Y495 Phosphorylation PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S527 O-Glycosylation GlyGen 29161034
S527 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569
S532 O-Glycosylation GlyGen 29161034
S532 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S556 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
C589 Methylation IEDB 31844290
K620 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus   UniProt 22358839
T658 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
K661 Ubiquitination PhosphoSitePlus
S666 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
T674 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
K707 Ubiquitination PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
S762 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
T774 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S799 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
K801 Ubiquitination PhosphoSitePlus
Y804 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K806 Ubiquitination PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
R894 Methylation PhosphoSitePlus
T903 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S904 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
T910 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S914 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S915 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S917 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S938 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S948 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S963 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S964 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 25813380, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S965 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
T989 Phosphorylation PhosphoSitePlus
S1041 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S1047 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S1048 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S1050 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S1051 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
T1073 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S1101 Phosphorylation PhosphoSitePlus
T1104 Phosphorylation PhosphoSitePlus
K1105 Acetylation PhosphoSitePlus
K1105 Ubiquitination PhosphoSitePlus
T1108 Phosphorylation PhosphoSitePlus
K1110 Ubiquitination PhosphoSitePlus
K1120 Ubiquitination PhosphoSitePlus
T1121 Phosphorylation PhosphoSitePlus
T1122 Phosphorylation PhosphoSitePlus
C1130 S-Nitrosylation dbSNO 24105792
K1140 Ubiquitination PhosphoSitePlus
Y1154 Phosphorylation PhosphoSitePlus
K1156 Ubiquitination PhosphoSitePlus
T1161 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S1163 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T1165 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1182 Phosphorylation PhosphoSitePlus
T1187 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
T1190 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
S1194 O-Glycosylation GlyGen 29161034
T1195 O-Glycosylation GlyGen 29161034
S1196 O-Glycosylation GlyGen 29161034
S1199 O-Glycosylation GlyGen 29161034
T1201 O-Glycosylation GlyGen 29161034
S1202 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35008409, 35138101, 30397120, 32885474, 34725712, 21740066, 29351928, 29913562, 29161034, 34019948, 32870666, 20305658, 34931806, 32119511, 34142147, 28510447, 34229054
T1213 Phosphorylation PhosphoSitePlus
K1217 Ubiquitination PhosphoSitePlus   UniProt 22358839
Site PTM Type PTM Enzyme Score Source PMID
Y331 Phosphorylation HPRD 20068231
S337 Phosphorylation HPRD 20068231
T338 Phosphorylation HPRD 20068231
S350 Phosphorylation HPRD 20068231
S521 Phosphorylation HPRD 17081983
S527 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18707149
S532 Phosphorylation HPRD 17081983
S799 Phosphorylation HPRD 17081983, 18767875, 18452278, ...19651622, 18669648, 18707149, 20166139, 20068231
Y804 Phosphorylation HPRD 19651622, 17081983, 20068231
T1121 Phosphorylation HPRD 20068231
T1122 Phosphorylation HPRD 20068231
T1161 Phosphorylation HPRD 17081983, 20068231
S1163 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231
T1165 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y331 Phosphorylation HPRD 20068231
S337 Phosphorylation HPRD 20068231
T338 Phosphorylation HPRD 20068231
S350 Phosphorylation HPRD 20068231
S521 Phosphorylation HPRD 17081983
S527 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18707149
S532 Phosphorylation HPRD 17081983
S799 Phosphorylation HPRD 17081983, 18767875, 18452278, ...19651622, 18669648, 18707149, 20166139, 20068231
Y804 Phosphorylation HPRD 19651622, 17081983, 20068231
T1106 Phosphorylation HPRD 20068231
T1107 Phosphorylation HPRD 20068231
T1146 Phosphorylation HPRD 17081983, 20068231
S1148 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231
T1150 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y331 Phosphorylation HPRD 20068231
S337 Phosphorylation HPRD 20068231
T338 Phosphorylation HPRD 20068231
S350 Phosphorylation HPRD 20068231
S521 Phosphorylation HPRD 17081983
S527 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18707149
S532 Phosphorylation HPRD 17081983
S799 Phosphorylation HPRD 17081983, 18767875, 18452278, ...19651622, 18669648, 18707149, 20166139, 20068231
Y804 Phosphorylation HPRD 19651622, 17081983, 20068231
T1007 Phosphorylation HPRD 20068231
T1008 Phosphorylation HPRD 20068231
T1047 Phosphorylation HPRD 17081983, 20068231
S1049 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231
T1051 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y331 Phosphorylation HPRD 20068231
S337 Phosphorylation HPRD 20068231
T338 Phosphorylation HPRD 20068231
S350 Phosphorylation HPRD 20068231
S760 Phosphorylation HPRD 17081983, 18767875, 18452278, ...19651622, 18669648, 18707149, 20166139, 20068231
Y765 Phosphorylation HPRD 19651622, 17081983, 20068231
T1082 Phosphorylation HPRD 20068231
T1083 Phosphorylation HPRD 20068231
T1122 Phosphorylation HPRD 17081983, 20068231
S1124 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231
T1126 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15436 (SEC23A) S207 O94979 (SEC31A) decreased_association eFIP 28486929


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T122 A122 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T122 I122 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S269 R269 Biomuta DOID:3571 / liver cancer [ cosmic ]
S323 L323 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
R411 T411 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R486 H486 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R486 C486 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y495 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S532 R532 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C589 S589 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K707 Q707 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R894 Q894 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T910 A910 Biomuta [ cosmic ]
S1041 L1041 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1048 R1048 Biomuta DOID:363 / uterine cancer [ icgc ]
S1049 L1049 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S1049 T1049 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1050 Y1050 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1051 K1051 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S1124 T1124 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1124 L1124 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
T1126 K1126 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1148 T1148 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1148 L1148 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
T1150 K1150 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
K1156 I1156 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1156 E1156 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S1163 L1163 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S1163 T1163 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1165 K1165 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1213 I1213 Biomuta DOID:5158 / pleural cancer [ cosmic ]