Protein Information

Cytoscape View


UniProt AC / UniProt ID O94953 / KDM4B_HUMAN
Protein Name Lysine-specific demethylase 4B
Gene Name Name: KDM4B
Synonyms:JHDM3B,JMJD2B,KIAA0876;
Organism Homo sapiens (Human)

PRO ID PR:O94953
DAG View
PRO Name lysine-specific demethylase 4B (human)
Definition A lysine-specific demethylase 4B that is encoded in the genome of human.
Short Label hKDM4B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94953 (KDM4B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K26 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus   RLIMS-P 28945223
K334 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus   RLIMS-P 28945223
S364 Phosphorylation PhosphoSitePlus
K381 Acetylation PhosphoSitePlus
K384 Acetylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K409 Acetylation PhosphoSitePlus
K409 Sumoylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
S566 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28945223, 23186163, 15302935, ...24275569, 19690332
S579 Phosphorylation PhosphoSitePlus
K602 Acetylation PhosphoSitePlus   UniProt 19608861
K602 Ubiquitination PhosphoSitePlus
S622 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S625 Phosphorylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
K928 Ubiquitination PhosphoSitePlus
K1032 Ubiquitination PhosphoSitePlus
K1056 Ubiquitination PhosphoSitePlus
T1065 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28945223, 23186163, 19690332
T1069 Phosphorylation PhosphoSitePlus
Y1078 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048095 (hKDM4B/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K52 R52 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y196 H196 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S197 N197 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K252 * Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K334 T334 Biomuta DOID:1909 / melanoma [ cosmic ]
S364 L364 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S622 P622 Biomuta DOID:3571 / liver cancer [ tcga ]
K907 E907 Biomuta DOID:169 / neuroendocrine tumor [ tcga ]
K928 N928 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y1078 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]