Protein Information

Cytoscape View


UniProt AC / UniProt ID O94925 / GLSK_HUMAN
Protein Name Glutaminase kidney isoform, mitochondrial precursor
Gene Name Name: GLS
Synonyms:GLS1,KIAA0838;
Organism Homo sapiens (Human)

PRO ID PR:O94925
DAG View
PRO Name glutaminase kidney isoform, mitochondrial (human)
Definition A glutaminase kidney isoform, mitochondrial that is encoded in the genome of human.
Short Label hGLS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94925 (GLS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K164 Acetylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
K311 Acetylation PhosphoSitePlus   UniProt 19608861
K311 Ubiquitination PhosphoSitePlus
S314 Phosphorylation RLIMS-P 29515166
K320 Acetylation PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus
Y370 Phosphorylation PhosphoSitePlus
R387 Methylation PhosphoSitePlus
Y393 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
N620 N-Glycosylation GlyGen 29671580
Site PTM Type PTM Enzyme Score Source PMID
S73 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S314 Phosphorylation PhosphoSitePlus
Y558 Phosphorylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9P2R7 (SUCLA2) S79 O94925 (GLS) unknown eFIP 33991485


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K158 T158 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y304 H304 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R387 * Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
R387 Q387 Biomuta DOID:363 / uterine cancer [ tcga ]
S449 I449 Biomuta DOID:3571 / liver cancer [ icgc ]