iPTMnet Report for O94921 (CDK14)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94921 / CDK14_HUMAN
Protein Name Cyclin-dependent kinase 14
Gene Name Name: CDK14
Synonyms:KIAA0834,PFTK1;
Organism Homo sapiens (Human)

PRO ID PR:O94921
DAG View
PRO Name cyclin-dependent kinase 14 (human)
Definition A cyclin-dependent kinase 14 that is encoded in the genome of human.
Short Label hCDK14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94921 (CDK14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation PhosphoSitePlus   UniProt 23186163
S26 Phosphorylation PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus   UniProt 23186163
T79 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
T105 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y135 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation HPRD 18691976
S101 Phosphorylation HPRD 18691976
S104 Phosphorylation HPRD 18691976
T107 Phosphorylation HPRD 18691976
S108 Phosphorylation HPRD 18691976
S116 Phosphorylation HPRD 18691976


O94921 (CDK14) as PTM Enzyme



Substrate Site Score Source PMID
O75581 (LRP6) S1490 Signor 20059949
P37802 (TAGLN2) S83 PhosphoSitePlus 21577206
P37802 (TAGLN2) S163 PhosphoSitePlus 21577206
P41236 (PPP1R2) S87 PhosphoSitePlus 25028520
Q8ND76 (CCNY) S33 PhosphoSitePlus 24794231
Q8ND76 (CCNY) T37 PhosphoSitePlus 24794231
Q8ND76 (CCNY) S71 Signor 24794231
Q8ND76 (CCNY) S73 Signor 24794231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S77 C77 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S95 C95 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T107 S107 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S123 W123 Biomuta DOID:1324 / lung cancer [ cosmic ]
T125 S125 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S145 C145 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]