Protein Information

Cytoscape View


UniProt AC / UniProt ID O94916 / NFAT5_HUMAN
Protein Name Nuclear factor of activated T-cells 5
Gene Name Name: NFAT5
Synonyms:KIAA0827,TONEBP;
Organism Homo sapiens (Human)

PRO ID PR:O94916
DAG View
PRO Name nuclear factor of activated T-cells 5 (human)
Definition A nuclear factor of activated T-cells 5 that is encoded in the genome of human.
Short Label hNFAT5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94916 (NFAT5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
Y28 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
C108 S-Nitrosylation dbSNO 26338901
S109 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus   UniProt 21209322
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus   UniProt 21209322
T135 Phosphorylation P06493 (CDK1) , Q00535 (CDK5) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21209322, 23186163
K137 Ubiquitination PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P 20585028, 20351292, 30190682
S145 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21209322, 22992674
S158 Phosphorylation Q8N752 (CSNK1A1L) , P48729 (CSNK1A1) PhosphoSitePlus 18411282
S220 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
K276 Sumoylation PhosphoSitePlus
K283 Sumoylation PhosphoSitePlus
T298 Phosphorylation RLIMS-P 22992674
K450 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K556 Sumoylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus   UniProt 23186163
K576 Ubiquitination PhosphoSitePlus
T594 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus
S1197 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15173573, 24614757
S1247 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15173573
S1367 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15173573
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 20068231
S17 Phosphorylation HPRD 20068231
T135 Phosphorylation HPRD 20068231
S145 Phosphorylation HPRD 20068231
S433 Phosphorylation HPRD 20068231
S560 Phosphorylation HPRD 18669648
S646 Phosphorylation HPRD 18669648
S648 Phosphorylation HPRD 18669648
S649 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T59 Phosphorylation HPRD 20068231
S69 Phosphorylation HPRD 20068231
K282 Acetylation PhosphoSitePlus
S357 Phosphorylation HPRD 20068231
S484 Phosphorylation HPRD 18669648
S570 Phosphorylation HPRD 18669648
S572 Phosphorylation HPRD 18669648
S573 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y46 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 20068231
S17 Phosphorylation HPRD 20068231
Y46 Phosphorylation PhosphoSitePlus
T153 Phosphorylation HPRD 20068231
S163 Phosphorylation HPRD 20068231
S451 Phosphorylation HPRD 20068231
S578 Phosphorylation HPRD 18669648
S664 Phosphorylation HPRD 18669648
S666 Phosphorylation HPRD 18669648
S667 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 P3 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S17 * Biomuta DOID:4362 / cervical cancer [ tcga ]
S266 I266 Biomuta DOID:363 / uterine cancer [ tcga ]
K468 N468 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K556 N556 Biomuta DOID:1324 / lung cancer [ cosmic ]
K576 R576 Biomuta DOID:363 / uterine cancer [ tcga ]
S600 I600 Biomuta DOID:3571 / liver cancer [ icgc ]
S646 A646 Biomuta DOID:1324 / lung cancer [ cosmic ]
S684 L684 Biomuta DOID:1324 / lung cancer [ tcga ]