iPTMnet Report for O94913 (PCF11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94913 / PCF11_HUMAN
Protein Name Pre-mRNA cleavage complex 2 protein Pcf11
Gene Name Name: PCF11
Synonyms:KIAA0824;
Organism Homo sapiens (Human)

PRO ID PR:O94913
DAG View
PRO Name pre-mRNA cleavage complex 2 protein Pcf11 (human)
Definition A pre-mRNA cleavage complex 2 protein Pcf11 that is encoded in the genome of human.
Short Label hPCF11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94913 (PCF11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378
S33 Phosphorylation HPRD 20068231
K64 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus   UniProt 29196535
T121 Phosphorylation PhosphoSitePlus   UniProt 29196535
K129 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S169 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163
S174 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
T178 O-Glycosylation GlyGen 28510447, 35138101, 30379171, ...29351928, 34019948, 35254053, 35132862, 35289036, 30620550
T178 Phosphorylation PhosphoSitePlus
S181 O-Glycosylation GlyGen 28510447, 35138101, 30379171, ...32938750, 34019948, 29351928, 35132862, 30620550, 35289036, 35254053
S181 Phosphorylation HPRD   PhosphoSitePlus 18669648
S182 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 19690332
S184 O-Glycosylation GlyGen 28510447, 35138101, 30379171, ...29351928, 34019948, 35254053, 35132862, 35289036, 30620550
S184 Phosphorylation HPRD   PhosphoSitePlus 19413330
S186 O-Glycosylation GlyGen 28510447, 35138101, 30379171, ...29351928, 34019948, 35254053, 35132862, 35289036, 30620550
S186 Phosphorylation HPRD   PhosphoSitePlus 18669648
T187 Phosphorylation HPRD   PhosphoSitePlus 18669648
K196 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
K337 Acetylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
S368 Phosphorylation HPRD   PhosphoSitePlus 19651622
S370 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S372 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
K382 Ubiquitination PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
K456 Sumoylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus   UniProt 23186163
S487 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18767875
S489 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983, ...20068231
S494 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19664995, 19651622, 20068231
S502 Phosphorylation PhosphoSitePlus
S509 O-Glycosylation GlyGen 28510447, 35138101, 30379171, ...29351928, 34019948, 35254053, 35132862, 35289036, 30620550
S509 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 20068231
S511 O-Glycosylation GlyGen 28510447, 35138101, 30379171, ...29351928, 34019948, 35254053, 35132862, 35289036, 30620550
S511 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 20068231
T513 Phosphorylation HPRD   PhosphoSitePlus 20068231
S514 Phosphorylation HPRD   PhosphoSitePlus 20068231
T535 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
T561 Phosphorylation PhosphoSitePlus
T569 Phosphorylation PhosphoSitePlus
T570 Phosphorylation PhosphoSitePlus
S593 Phosphorylation phospho.ELM 17081983
S624 Phosphorylation PhosphoSitePlus
S633 Phosphorylation HPRD   PhosphoSitePlus 20068231
S645 Phosphorylation HPRD   PhosphoSitePlus   UniProt 24275569, 20068231
K661 Ubiquitination PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
S705 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231
K723 Ubiquitination PhosphoSitePlus
S728 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
S756 Phosphorylation PhosphoSitePlus
T766 Phosphorylation PhosphoSitePlus
S777 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
R779 Methylation PhosphoSitePlus
T785 Phosphorylation PhosphoSitePlus   UniProt 23186163, 18220336
R790 Methylation PhosphoSitePlus
S794 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
R805 Methylation PhosphoSitePlus   UniProt 24129315
R820 Methylation PhosphoSitePlus   UniProt 24129315
R833 Methylation PhosphoSitePlus   UniProt 24129315
R847 Methylation PhosphoSitePlus
S851 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163
R855 Methylation PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
R864 Methylation PhosphoSitePlus
R877 Methylation PhosphoSitePlus
R882 Methylation PhosphoSitePlus
R890 Methylation PhosphoSitePlus
R903 Methylation PhosphoSitePlus
R908 Methylation PhosphoSitePlus
R916 Methylation PhosphoSitePlus
R929 Methylation PhosphoSitePlus   UniProt 24129315
R942 Methylation PhosphoSitePlus   UniProt 24129315
R955 Methylation PhosphoSitePlus   UniProt 24129315
R968 Methylation PhosphoSitePlus
R981 Methylation PhosphoSitePlus   UniProt 24129315
R994 Methylation PhosphoSitePlus   UniProt 24129315
R1007 Methylation PhosphoSitePlus   UniProt 24129315
R1019 Methylation PhosphoSitePlus
R1030 Methylation PhosphoSitePlus
R1038 Methylation PhosphoSitePlus
S1047 Phosphorylation PhosphoSitePlus
R1051 Methylation PhosphoSitePlus
R1062 Methylation PhosphoSitePlus
R1065 Methylation PhosphoSitePlus
R1074 Methylation PhosphoSitePlus
R1086 Methylation PhosphoSitePlus
R1093 Methylation PhosphoSitePlus   UniProt 24129315
R1104 Methylation PhosphoSitePlus   UniProt 24129315
T1114 Phosphorylation PhosphoSitePlus
R1115 Methylation PhosphoSitePlus
S1161 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S1186 Phosphorylation PhosphoSitePlus
Y1189 Phosphorylation PhosphoSitePlus
T1211 Phosphorylation PhosphoSitePlus
S1218 Phosphorylation PhosphoSitePlus
K1275 Acetylation PhosphoSitePlus
K1275 Ubiquitination PhosphoSitePlus
K1278 Sumoylation PhosphoSitePlus
K1278 Ubiquitination PhosphoSitePlus
S1376 Phosphorylation PhosphoSitePlus
S1406 Phosphorylation PhosphoSitePlus
K1419 Ubiquitination PhosphoSitePlus
T1420 Phosphorylation PhosphoSitePlus
Y1482 Phosphorylation PhosphoSitePlus
T1485 Phosphorylation PhosphoSitePlus
S1486 Phosphorylation PhosphoSitePlus
S1487 Phosphorylation PhosphoSitePlus
T1491 Phosphorylation PhosphoSitePlus
S1493 Phosphorylation PhosphoSitePlus
S1495 Phosphorylation PhosphoSitePlus
T1497 Phosphorylation PhosphoSitePlus
K1511 Sumoylation PhosphoSitePlus
S1520 Phosphorylation HPRD   PhosphoSitePlus 18669648
K1524 Sumoylation PhosphoSitePlus
T1530 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15302935, 23186163, 18452278
C1534 S-Nitrosylation dbSNO 26338901
S1538 Phosphorylation PhosphoSitePlus
T1541 Phosphorylation PhosphoSitePlus
K1546 Sumoylation PhosphoSitePlus
S1554 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S33 R33 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S120 Y120 Biomuta DOID:363 / uterine cancer [ icgc ]
K196 N196 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K211 N211 Biomuta DOID:363 / uterine cancer [ icgc ]
S312 N312 Biomuta DOID:363 / uterine cancer [ icgc ]
T327 I327 Biomuta DOID:3571 / liver cancer [ cosmic ]
S368 L368 Biomuta DOID:1319 / brain cancer [ icgc ]
S368 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K456 I456 Biomuta DOID:2021 / placenta cancer [ cosmic ]
S494 A494 Biomuta DOID:263 / kidney cancer [ icgc ]
S514 L514 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T561 I561 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S593 T593 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S633 P633 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K667 N667 Biomuta DOID:1324 / lung cancer [ cosmic ]
R779 Q779 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
R833 L833 Biomuta DOID:1324 / lung cancer [ cosmic ]
R833 Q833 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R833 W833 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R847 W847 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R847 Q847 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R882 H882 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
R890 G890 Biomuta DOID:4159 / skin cancer [ cosmic ]
R890 M890 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R903 T903 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R908 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
R955 M955 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R968 I968 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1019 I1019 Biomuta DOID:363 / uterine cancer [ icgc ]
R1062 I1062 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1065 S1065 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1093 I1093 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1114 K1114 Biomuta DOID:1324 / lung cancer [ cosmic ]
R1115 I1115 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
T1420 S1420 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T1485 A1485 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1495 G1495 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1495 N1495 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1520 G1520 Biomuta DOID:1324 / lung cancer [ cosmic ]