Protein Information

Cytoscape View

UniProt AC / UniProt ID O94907 / DKK1_HUMAN
Protein Name Dickkopf-related protein 1 precursor
Gene Name Name: DKK1
Organism Homo sapiens (Human)

PRO ID PR:O94907
DAG View
PRO Name dickkopf-related protein 1 (human)
Definition A dickkopf-related protein 1 that is encoded in the genome of human.
Short Label hDKK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O94907 (DKK1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S61 O-Glycosylation GlyGen   UniProt 21805521
Y68 O-Glycosylation GlyGen 23584533, 25813380
N131 N-Glycosylation GlyGen 23090970, 24190977
Y132 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
T155 O-Glycosylation PhosphoSitePlus
S163 O-Glycosylation PhosphoSitePlus
T164 O-Glycosylation PhosphoSitePlus
Y168 O-Glycosylation GlyGen 25813380
S169 O-Glycosylation PhosphoSitePlus
T172 O-Glycosylation PhosphoSitePlus
T173 O-Glycosylation PhosphoSitePlus
Y179 O-Glycosylation GlyGen 25813380
T181 O-Glycosylation PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
N256 N-Glycosylation GlyGen   UniProt 21805521
S257 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 I61 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
N131 H131 Biomuta DOID:0070003 / blastoma [ cosmic ]
T155 I155 Biomuta DOID:1324 / lung cancer [ tcga ]
S163 I163 Biomuta DOID:3571 / liver cancer [ icgc ]
Y168 F168 Biomuta DOID:1909 / melanoma [ cosmic ]
T172 P172 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T173 A173 Biomuta DOID:3070 / malignant glioma [ tcga ]
S255 I255 Biomuta DOID:3571 / liver cancer [ icgc ]
S257 F257 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]