iPTMnet Report for O94907 (DKK1)
Protein Information
| UniProt AC / UniProt ID | O94907 / DKK1_HUMAN |
| Protein Name | Dickkopf-related protein 1 precursor |
| Gene Name | Name: DKK1 ORFNames:UNQ492/PRO1008; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O94907 |
| PRO Name | dickkopf-related protein 1 (human) |
| Definition | A dickkopf-related protein 1 that is encoded in the genome of human. |
| Short Label | hDKK1 |
| Category | organism-gene |
DAG ViewO94907 (DKK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S61 | O-Glycosylation | score4 | GlyGen UniProt | 25813380, 21805521 | ||
| Y68 | O-Glycosylation | score1 | GlyGen | 23584533, 25813380 | ||
| T76 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| S99 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| N131 | N-Glycosylation | score1 | GlyGen | 23090970, 24190977 | ||
| Y132 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S140 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S141 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T153 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| T155 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| S163 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| T164 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| Y168 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| S169 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| T172 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| T173 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| S175 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| Y179 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| T181 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| T221 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S255 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N256 | N-Glycosylation | score3 | GlyGen UniProt | 21805521 | ||
| S257 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S258 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T262 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S61 | I61 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T76 | N76 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S99 | N99 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| N131 | H131 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T155 | A155 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T155 | I155 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y168 | F168 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S169 | F169 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T172 | P172 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| T173 | A173 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
| S175 | P175 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| T221 | A221 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S255 | T255 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| S257 | F257 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] |
