iPTMnet Report for O94906 (PRPF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94906 / PRP6_HUMAN
Protein Name Pre-mRNA-processing factor 6
Gene Name Name: PRPF6
Synonyms:C20orf14;
Organism Homo sapiens (Human)

PRO ID PR:O94906
DAG View
PRO Name pre-mRNA-processing factor 6 (human)
Definition A pre-mRNA-processing factor 6 that is encoded in the genome of human.
Short Label hPRPF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94906 (PRPF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y17 Phosphorylation PhosphoSitePlus
R23 Methylation PhosphoSitePlus
T26 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
R31 Methylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
R47 Methylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 24275569
K146 Methylation PhosphoSitePlus
K146 Sumoylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
K178 Sumoylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
T180 Phosphorylation PhosphoSitePlus   UniProt 23186163
K189 Ubiquitination PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
T266 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
K271 Ubiquitination PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
T275 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S279 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K324 Ubiquitination PhosphoSitePlus
K341 Sumoylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
R351 Methylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
R464 Methylation PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
C558 Methylation IEDB 31844290
K573 Ubiquitination PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
K585 Acetylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
C604 Methylation IEDB 31844290
K606 Ubiquitination PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
K618 Sumoylation PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
K650 Sumoylation PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
S670 O-Glycosylation GlyGen 30379171
S671 O-Glycosylation GlyGen 30379171
K680 Ubiquitination PhosphoSitePlus
K683 Sumoylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
R703 Methylation PhosphoSitePlus
Y705 Phosphorylation PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
K715 Sumoylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K722 Sumoylation PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
T798 Phosphorylation PhosphoSitePlus
T828 O-Glycosylation GlyGen 30379171, 34019948, 28510447, ...25367160
K829 Acetylation PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
T858 Phosphorylation PhosphoSitePlus
K883 Sumoylation PhosphoSitePlus
K917 Ubiquitination PhosphoSitePlus
K924 Ubiquitination PhosphoSitePlus
K925 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T26 Phosphorylation HPRD 18452278
T30 Phosphorylation HPRD 18452278
S32 Phosphorylation HPRD 18452278
T266 Phosphorylation HPRD 18669648, 19691289, 20068231
Y273 Phosphorylation HPRD 18452278
T275 Phosphorylation HPRD 18669648, 20068231
S279 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R31 Q31 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R31 W31 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R47 C47 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R47 H47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y105 C105 Biomuta DOID:1324 / lung cancer [ cosmic ]
K146 R146 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y176 C176 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T180 I180 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S199 L199 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T227 M227 Biomuta DOID:184 / bone cancer [ cosmic ]
T275 M275 Biomuta DOID:3571 / liver cancer [ cosmic ]
S279 F279 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K341 M341 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K574 N574 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K606 R606 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K680 N680 Biomuta DOID:1319 / brain cancer [ cosmic ]
R703 Q703 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R703 W703 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K715 N715 Biomuta DOID:1319 / brain cancer [ icgc ]
K722 N722 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K768 N768 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K775 N775 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S783 F783 Biomuta DOID:4159 / skin cancer [ cosmic ]
S853 N853 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K924 N924 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K925 N925 Biomuta DOID:3571 / liver cancer [ cosmic ]