iPTMnet Report for O94905 (ERLIN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94905 / ERLN2_HUMAN
Protein Name Erlin-2
Gene Name Name: ERLIN2
Synonyms:C8orf2,SPFH2;ORFNames:UNQ2441/PRO5003/PRO9924;
Organism Homo sapiens (Human)

PRO ID PR:O94905
DAG View
PRO Name erlin-2 (human)
Definition An erlin-2 that is encoded in the genome of human.
Short Label hERLIN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94905 (ERLIN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
N106 N-Glycosylation GlyGen   UniProt 29741879, 17502376, 24190977
T108 O-Glycosylation GlyGen 27114449, 32574038, 22661428, ...34019948, 35289036, 34229054
K113 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
T334 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T336 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380, 22661428
Site PTM Type PTM Enzyme Score Source PMID
N106 N-Glycosylation PRO 29741879


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 Y61 Biomuta DOID:363 / uterine cancer [ icgc ]
K241 N241 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y263 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y263 C263 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T277 N277 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T334 M334 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]