iPTMnet Report for O94903 (PLPBP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94903 / PLPHP_HUMAN
Protein Name Pyridoxal phosphate homeostasis protein
Gene Name Name: PLPBP
Synonyms:PROSC;
Organism Homo sapiens (Human)

PRO ID PR:O94903
DAG View
PRO Name pyridoxal phosphate homeostasis protein (human)
Definition A pyridoxal phosphate homeostasis protein PLPBP that is encoded in the genome of human.
Short Label hPLPBP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94903 (PLPBP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus   UniProt 23186163
K47 Ubiquitination PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
C172 Methylation IEDB 31844290
S226 Phosphorylation PhosphoSitePlus   UniProt 24275569
S244 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163, 24275569
T245 Phosphorylation PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K47 Q47 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S135 C135 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C172 F172 Biomuta DOID:4159 / skin cancer [ cosmic ]
S226 F226 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S226 P226 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T245 M245 Biomuta DOID:3571 / liver cancer [ cosmic ]
S253 * Biomuta DOID:363 / uterine cancer [ cosmic ]