iPTMnet Report for O94885 (SASH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94885 / SASH1_HUMAN
Protein Name SAM and SH3 domain-containing protein 1
Gene Name Name: SASH1
Synonyms:KIAA0790,PEPE1;
Organism Homo sapiens (Human)

PRO ID PR:O94885
DAG View
PRO Name SAM and SH3 domain-containing protein 1 (human)
Definition A SAM and SH3 domain-containing protein 1 that is encoded in the genome of human.
Short Label hSASH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94885 (SASH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y69 Phosphorylation PhosphoSitePlus
S90 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 17081983, 18220336, ...19648646, 18077418, 19651622, 18669648
S101 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18077418
S104 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
S248 Phosphorylation HPRD   PhosphoSitePlus 19651622
S267 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
S407 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664994, 23186163, 18212344, ...24275569
S417 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
T572 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
S614 Phosphorylation HPRD   PhosphoSitePlus   UniProt 24275569, 18452278
Y697 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
S721 Phosphorylation HPRD   PhosphoSitePlus 19664994
S725 Phosphorylation PhosphoSitePlus
Y728 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
Y766 Phosphorylation PhosphoSitePlus
S813 Phosphorylation HPRD   PhosphoSitePlus 19664994
S817 Phosphorylation PhosphoSitePlus
S821 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus   RLIMS-P 21152398
S839 Phosphorylation PhosphoSitePlus   RLIMS-P 21152398
T858 Phosphorylation PhosphoSitePlus   UniProt 24275569
S901 Phosphorylation PhosphoSitePlus
R920 Methylation PhosphoSitePlus
S923 Phosphorylation PhosphoSitePlus
Y932 Phosphorylation PhosphoSitePlus
S992 Phosphorylation PhosphoSitePlus
S1013 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
S1028 Phosphorylation PhosphoSitePlus
S1031 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus
S1086 Phosphorylation PhosphoSitePlus
S1233 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y69 F69 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S90 F90 Biomuta DOID:4159 / skin cancer [ cosmic ]
S101 I101 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S114 L114 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T123 A123 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S135 L135 Biomuta DOID:184 / bone cancer [ cosmic ]
S170 A170 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S170 L170 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S297 L297 Biomuta DOID:363 / uterine cancer [ icgc ]
Y307 C307 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T333 A333 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T353 A353 Biomuta DOID:1324 / lung cancer [ cosmic ]
S355 R355 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S355 G355 Biomuta DOID:1324 / lung cancer [ cosmic ]
S374 F374 Biomuta DOID:4159 / skin cancer [ cosmic ]
T389 P389 Biomuta DOID:4159 / skin cancer [ icgc ]
S449 F449 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S486 C486 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S507 F507 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S725 P725 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y766 H766 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S817 F817 Biomuta DOID:4159 / skin cancer [ cosmic ]
S837 F837 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S901 Y901 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R920 C920 Biomuta DOID:4159 / skin cancer [ cosmic ]
R920 H920 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S923 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S992 R992 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1013 T1013 Biomuta DOID:4606 / bile duct cancer [ cosmic ]