iPTMnet Report for O94875 (SORBS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94875 / SRBS2_HUMAN
Protein Name Sorbin and SH3 domain-containing protein 2
Gene Name Name: SORBS2
Synonyms:ARGBP2,KIAA0777;
Organism Homo sapiens (Human)

PRO ID PR:O94875
DAG View
PRO Name sorbin and SH3 domain-containing protein 2 (human)
Definition A sorbin and SH3 domain-containing protein 2 that is encoded in the genome of human.
Short Label hSORBS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94875 (SORBS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y13 Phosphorylation UniProt 24275569
S14 Phosphorylation UniProt 20068231, 24275569
H27 Phosphorylation UniProt 24275569
G28 Phosphorylation UniProt 20068231, 24275569
Y72 Phosphorylation PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus   UniProt 24275569
S157 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S166 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
Y232 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus   UniProt 24275569
S235 Phosphorylation PhosphoSitePlus
I236 Phosphorylation UniProt 24275569
S239 Phosphorylation PhosphoSitePlus   UniProt 24275569
S245 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
K258 Phosphorylation UniProt 18669648, 20068231
S259 Phosphorylation PhosphoSitePlus   UniProt 24275569
E260 Phosphorylation UniProt 18669648, 20068231, 24275569
S273 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus   UniProt 18669648
S278 Phosphorylation PhosphoSitePlus
G280 Phosphorylation UniProt 24275569
V282 Phosphorylation UniProt 24275569
S287 Phosphorylation PhosphoSitePlus   UniProt 24275569
S288 O-Glycosylation GlyGen 23271734, 35289036, 28657654, ...30379171
S288 Phosphorylation PhosphoSitePlus
T290 O-Glycosylation GlyGen 23271734, 35289036, 28657654, ...30379171
T292 Phosphorylation PhosphoSitePlus   UniProt 24275569
S294 Phosphorylation PhosphoSitePlus
F295 Phosphorylation UniProt 24275569
S297 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus   UniProt 20068231
S299 Phosphorylation PhosphoSitePlus   UniProt 20068231
S301 Phosphorylation PhosphoSitePlus   UniProt 18669648
S302 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S304 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
A306 Phosphorylation UniProt 18669648, 20068231, 24275569
D311 Phosphorylation UniProt 24275569
P316 Phosphorylation UniProt 24275569
S320 Phosphorylation UniProt 24275569
S322 Phosphorylation UniProt 24275569
G326 Phosphorylation UniProt 24275569
H341 Phosphorylation UniProt 24275569
V344 Phosphorylation UniProt 18669648, 20068231
R346 Phosphorylation UniProt 18669648, 20068231, 24275569
E366 Phosphorylation UniProt 24275569
S381 Phosphorylation UniProt 24275569
D413 Phosphorylation UniProt 24275569
K415 Phosphorylation UniProt 24275569
R437 Phosphorylation UniProt 18669648, 20068231
R439 Phosphorylation UniProt 18669648, 20068231, 24275569
I459 Phosphorylation UniProt 24275569
K474 Phosphorylation UniProt 24275569
S522 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
T535 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus
S733 Phosphorylation IEDB 35494241
S750 Phosphorylation PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus   UniProt 24275569
T860 Phosphorylation PhosphoSitePlus
K875 Acetylation PhosphoSitePlus
T889 Phosphorylation PhosphoSitePlus
Y891 Phosphorylation PhosphoSitePlus
Y901 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
Y916 Phosphorylation PhosphoSitePlus
T921 Phosphorylation PhosphoSitePlus
Y976 Phosphorylation PhosphoSitePlus
Y993 Phosphorylation PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus
Y1007 Phosphorylation PhosphoSitePlus
S1015 Phosphorylation PhosphoSitePlus
S1017 Phosphorylation PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus
S1023 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1025 Phosphorylation PhosphoSitePlus
T1053 Phosphorylation PhosphoSitePlus
T1091 Phosphorylation PhosphoSitePlus
Y1096 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S154 Phosphorylation HPRD 20068231
S157 Phosphorylation HPRD 20166139, 18669648, 20068231
S165 Phosphorylation HPRD 18669648, 20068231
S166 Phosphorylation HPRD 18669648, 17081983, 20068231
S211 Phosphorylation HPRD 18212344
S230 Phosphorylation HPRD 20166139
S259 Phosphorylation HPRD 18212344, 18669648, 20166139, ...17924679, 20068231, 20068230
S273 Phosphorylation HPRD 20068231
T277 Phosphorylation HPRD 19651622, 18669648, 20068231, ...17924679
S278 Phosphorylation HPRD 18669648, 20068231
S298 Phosphorylation HPRD 18669648, 20068231
S299 Phosphorylation HPRD 19651622, 18669648, 20068231
S301 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S302 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231, 20068230
S304 Phosphorylation HPRD 20068231
S838 Phosphorylation HPRD 17081983, 20068231
S915 Phosphorylation HPRD 20068231
S1015 Phosphorylation HPRD 20166139, 20068231
S1017 Phosphorylation HPRD 20166139
S1018 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
T69 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
T320 Phosphorylation PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
T342 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
Y390 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus
S200 Phosphorylation HPRD 20068231
S203 Phosphorylation HPRD 20166139, 18669648, 20068231
S211 Phosphorylation HPRD 18669648, 20068231
S212 Phosphorylation HPRD 18669648, 17081983, 20068231
S257 Phosphorylation HPRD 18212344
S316 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S352 Phosphorylation HPRD   PhosphoSitePlus 18212344, 18669648, 20166139, ...17924679, 20068231, 20068230
S366 Phosphorylation HPRD 20068231
T370 Phosphorylation HPRD 19651622, 18669648, 20068231, ...17924679
S371 Phosphorylation HPRD 18669648, 20068231
S387 Phosphorylation PhosphoSitePlus
S391 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S392 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231
S394 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S395 Phosphorylation HPRD   PhosphoSitePlus 15302935, 19651622, 18669648, ...20068231, 20068230
S397 Phosphorylation HPRD   PhosphoSitePlus 20068231
S404 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S409 Phosphorylation PhosphoSitePlus
S481 Phosphorylation HPRD 20068231
Y559 Phosphorylation PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
S581 Phosphorylation HPRD 20166139, 20068231
S583 Phosphorylation HPRD 20166139
S584 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
S258 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
T279 Phosphorylation PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
Y350 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
Y350 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
G28 C28 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T120 A120 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S152 Y152 Biomuta DOID:4159 / skin cancer [ cosmic ]
S211 T211 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y215 C215 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S234 Y234 Biomuta DOID:363 / uterine cancer [ icgc ]
S257 T257 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
E260 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S273 N273 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y284 C284 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S287 L287 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S294 Y294 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y301 C301 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
D311 N311 Biomuta DOID:4159 / skin cancer [ cosmic ]
G326 C326 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S339 Y339 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
V344 A344 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R346 W346 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R346 Q346 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S351 R351 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T355 P355 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S365 Y365 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S366 N366 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
E366 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S380 F380 Biomuta DOID:4159 / skin cancer [ cosmic ]
S382 Y382 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S387 Y387 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y394 C394 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S404 Y404 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R437 K437 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R437 M437 Biomuta DOID:363 / uterine cancer [ icgc ]
R439 K439 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S444 R444 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T448 P448 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S452 Y452 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S473 F473 Biomuta DOID:4159 / skin cancer [ cosmic ]
S545 Y545 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y573 H573 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S712 L712 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T860 I860 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1007 H1007 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1096 C1096 Biomuta DOID:363 / uterine cancer [ icgc ]