Protein Information

Cytoscape View


UniProt AC / UniProt ID O94874 / UFL1_HUMAN
Protein Name E3 UFM1-protein ligase 1
Gene Name Name: UFL1
Synonyms:KIAA0776;
Organism Homo sapiens (Human)

PRO ID PR:O94874
DAG View
PRO Name E3 UFM1-protein ligase 1 (human)
Definition An E3 UFM1-protein ligase 1 that is encoded in the genome of human.
Short Label hUFL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94874 (UFL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
R9 Methylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
R122 Methylation PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
K386 Acetylation PhosphoSitePlus
K389 Acetylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
R433 Methylation PhosphoSitePlus
R441 Methylation PhosphoSitePlus
S458 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18318008, ...24275569, 20068231
S462 Phosphorylation PhosphoSitePlus   RLIMS-P 30886146
S464 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
T536 Phosphorylation PhosphoSitePlus
Y548 Phosphorylation PhosphoSitePlus
K571 Acetylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
C641 S-Nitrosylation dbSNO 26338901
C649 S-Nitrosylation dbSNO 26338901
K654 Ubiquitination PhosphoSitePlus
C708 S-Nitrosylation dbSNO 19483679
K745 Ubiquitination PhosphoSitePlus
T746 Phosphorylation PhosphoSitePlus
Y751 Phosphorylation PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus
S778 Phosphorylation PhosphoSitePlus
K780 Ubiquitination PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
S790 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
Site PTM Type PTM Enzyme Score Source PMID
T426 Phosphorylation HPRD 20068231
S431 Phosphorylation HPRD 20068231
S458 Phosphorylation HPRD 19651622, 17081983, 20068231
S465 Phosphorylation HPRD 20068231
S790 Phosphorylation HPRD 15302935


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K43 N43 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S63 G63 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R73 Q73 Biomuta DOID:363 / uterine cancer [ tcga ]
Y266 C266 Biomuta DOID:1324 / lung cancer [ cosmic ]
R441 K441 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S458 R458 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K507 Q507 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T531 R531 Biomuta DOID:1324 / lung cancer [ cosmic ]
T531 M531 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
C649 F649 Biomuta DOID:3571 / liver cancer [ icgc ]
K654 E654 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S778 F778 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S789 L789 Biomuta DOID:1909 / melanoma [ tcga ]
S790 F790 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]