iPTMnet Report for O94822 (LTN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94822 / LTN1_HUMAN
Protein Name E3 ubiquitin-protein ligase listerin
Gene Name Name: LTN1
Synonyms:C21orf10,C21orf98,KIAA0714,RNF160,ZNF294;ORFNames:HSPC087;
Organism Homo sapiens (Human)

PRO ID PR:O94822
DAG View
PRO Name E3 ubiquitin-protein ligase listerin (human)
Definition An E3 ubiquitin-protein ligase listerin that is encoded in the genome of human.
Short Label hLTN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94822 (LTN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus
R20 Methylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
C237 Methylation IEDB 31844290
K250 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K259 Acetylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
T619 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
T706 O-Glycosylation GlyGen 28510447, 29351928
K707 Ubiquitination PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
K992 Ubiquitination PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus
K1136 Ubiquitination PhosphoSitePlus
K1140 Ubiquitination PhosphoSitePlus
T1336 O-Glycosylation GlyGen 28510447, 29351928
S1337 O-Glycosylation GlyGen 28510447, 29351928
K1355 Ubiquitination PhosphoSitePlus
K1362 Ubiquitination PhosphoSitePlus
Y1499 Phosphorylation PhosphoSitePlus
Y1502 Phosphorylation PhosphoSitePlus
K1740 Ubiquitination PhosphoSitePlus
Y1747 Phosphorylation PhosphoSitePlus
K1755 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R20 Q20 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R20 G20 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
K131 N131 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K200 E200 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
C237 R237 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K259 T259 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K378 Q378 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K992 N992 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1337 F1337 Biomuta DOID:363 / uterine cancer [ icgc ]
K1355 Q1355 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1499 H1499 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]