iPTMnet Report for O94806 (PRKD3)
Protein Information
| UniProt AC / UniProt ID | O94806 / KPCD3_HUMAN |
| Protein Name | Serine/threonine-protein kinase D3 |
| Gene Name | Name: PRKD3 Synonyms:EPK2,PRKCN; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O94806 |
| PRO Name | serine/threonine-protein kinase D3 (human) |
| Definition | A serine/threonine-protein kinase D3 that is encoded in the genome of human. |
| Short Label | hPRKD3 |
| Category | organism-gene |
DAG ViewO94806 (PRKD3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S6 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976 | ||
| S9 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S13 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S27 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 18669648, 20068231, ... | ||
| S30 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S31 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| T34 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S37 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976 | ||
| S41 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 23186163, 19369195, ... | ||
| S44 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
| S46 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S213 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 19369195 | ||
| S216 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 19369195 | ||
| S252 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S254 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K293 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S315 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T360 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S364 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 23186163, 16964243, ... | ||
| T389 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S391 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18220336 | ||
| S395 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S406 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K408 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S415 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T446 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y456 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S463 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T535 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 19369195 | ||
| S543 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K605 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K615 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K730 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S731 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 24840177, 16198087, 18692497 | ||
| S731 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 18692497 | |
| S735 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 24840177, 16198087, 18220336 | ||
| T739 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y742 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K816 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S9 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S13 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S27 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 18669648, ... | ||
| S30 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 | ||
| S31 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 | ||
| S37 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S41 | Phosphorylation | score0 | HPRD | 19651622, 18691976, 18669648, ... | ||
| S44 | Phosphorylation | score0 | HPRD | 19651622, 18691976, 18669648, ... | ||
| S213 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S216 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S223 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S237 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S247 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S252 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S364 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 16964243 | ||
| S391 | Phosphorylation | score0 | HPRD | 18691976, 18767875 | ||
| S393 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S395 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T535 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S539 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T542 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S543 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S731 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S735 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T739 | Phosphorylation | score0 | HPRD | 18767875 |
O94806 (PRKD3) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P49840 (GSK3A) | S21 | score4 | HPRD neXtProt | 11884598, 19413330, 12054501, ... | |
| P49841 (GSK3B) | S9 | score2 | neXtProt | 11884598 | |
| Q04206 (RELA) | S276 | score2 | RLIMS-P+ | 22797919 | |
| Q04206 (RELA) | S536 | score2 | RLIMS-P+ | 22797919 | |
| Q15139 (PRKD1) | S738 | score2 | PhosphoSitePlus | 15383279 | |
| Q15139 (PRKD1) | S742 | score2 | PhosphoSitePlus | 15383279 | |
| Q9BST9 (RTKN) | S448 | score2 | neXtProt | 22228765 | |
| Q9NRA0 (SPHK2) | S419 | score2 | neXtProt | 17635916 | |
| Q9NRA0 (SPHK2) | S421 | score2 | neXtProt | 17635916 | |
| Q9UQL6 (HDAC5) | S498 | score3 | neXtProt PhosphoSitePlus | 16584705 | |
| Q9Y2X7 (GIT1) | S46 | score3 | neXtProt PhosphoSitePlus Signor | 22893698 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S6 | P6 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| T34 | M34 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S41 | C41 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S41 | P41 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S213 | * | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| S395 | N395 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S406 | T406 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| Y456 | F456 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| T535 | I535 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S539 | R539 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K730 | T730 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
 |