Protein Information

Cytoscape View


UniProt AC / UniProt ID O94782 / UBP1_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 1
Gene Name Name: USP1
Organism Homo sapiens (Human)

PRO ID PR:O94782
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 1 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 1 that is encoded in the genome of human.
Short Label hUSP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94782 (USP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD   PhosphoSitePlus 20068231
S13 Phosphorylation HPRD   PhosphoSitePlus 17924679
S16 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
T33 Phosphorylation PhosphoSitePlus
S42 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 31086816, 23186163, ...23116119, 20068231
K48 Ubiquitination PhosphoSitePlus
S67 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 23186163, 18452278, ...18669648, 23116119
K73 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K124 Sumoylation PhosphoSitePlus
K130 Acetylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K232 Sumoylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S248 Phosphorylation HPRD 20068231
S273 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
S313 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 23186163, 25744535, ...18669648, 23116119, 20068231
S323 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S331 Phosphorylation RLIMS-P 31086816
K343 Ubiquitination PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S475 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17322306, 19651622
K483 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
T529 Phosphorylation HPRD   PhosphoSitePlus 20068231
K610 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
Y678 Phosphorylation PhosphoSitePlus
Y681 Phosphorylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
K716 Acetylation PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
S768 Phosphorylation HPRD   PhosphoSitePlus 20068231
S770 Phosphorylation HPRD 20068231
S772 Phosphorylation HPRD   PhosphoSitePlus 20068231
T774 Phosphorylation HPRD 20068231
S775 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O94782 (USP1) S331 O95863 (SNAI1) unknown eFIP 31086816
Phosphorylation O94782 (USP1) S313 Q8TAF3 (WDR48) unknown eFIP 25744535
Phosphorylation O94782 (USP1) S313 Q8TAF3 (WDR48) unknown eFIP 23116119


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K73 N73 Biomuta DOID:1612 / breast cancer [ tcga ]
K124 N124 Biomuta DOID:3571 / liver cancer [ icgc ]
K130 E130 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K224 E224 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K232 N232 Biomuta DOID:3571 / liver cancer [ icgc ]
S248 I248 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S323 C323 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K343 T343 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S398 Y398 Biomuta DOID:3070 / malignant glioma [ tcga ]
S398 C398 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S475 Y475 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K523 N523 Biomuta DOID:363 / uterine cancer [ tcga ]
K623 Q623 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K741 N741 Biomuta DOID:3571 / liver cancer [ icgc ]