iPTMnet Report for O94762 (RECQL5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94762 / RECQ5_HUMAN
Protein Name ATP-dependent DNA helicase Q5
Gene Name Name: RECQL5
Synonyms:RECQ5;
Organism Homo sapiens (Human)

PRO ID PR:O94762
DAG View
PRO Name ATP-dependent DNA helicase Q5 (human)
Definition An ATP-dependent DNA helicase Q5 that is encoded in the genome of human.
Short Label hRECQL5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94762 (RECQL5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K22 Ubiquitination PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
T31 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
C61 Methylation IEDB 31844290
K103 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K232 Methylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
T456 O-Glycosylation GlyGen 30379171
T456 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
Y478 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y508 Phosphorylation PhosphoSitePlus
T568 Phosphorylation PhosphoSitePlus
T570 Phosphorylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
T676 Phosphorylation PhosphoSitePlus
C698 Methylation IEDB 31844290
S720 Phosphorylation PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28575661, 23186163
R745 Methylation PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
S815 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T839 Phosphorylation PhosphoSitePlus   UniProt 23186163
T845 Phosphorylation PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
C977 S-Nitrosylation dbSNO 26338901
C987 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S727 Phosphorylation HPRD 19651622
S815 Phosphorylation HPRD 18669648, 19664994
T821 Phosphorylation HPRD 20068231
T839 Phosphorylation HPRD 19007248
Site PTM Type PTM Enzyme Score Source PMID
S419 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K110 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K248 N248 Biomuta DOID:1319 / brain cancer [ icgc ]
S488 F488 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T570 I570 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S727 F727 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R745 W745 Biomuta DOID:4159 / skin cancer [ cosmic ]
R745 Q745 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S815 L815 Biomuta DOID:1324 / lung cancer [ cosmic ]
C987 S987 Biomuta DOID:9256 / colorectal cancer [ cosmic ]