iPTMnet Report for O94759 (TRPM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94759 / TRPM2_HUMAN
Protein Name Transient receptor potential cation channel subfamily M member 2
Gene Name Name: TRPM2
Synonyms:EREG1;
Organism Homo sapiens (Human)

PRO ID PR:O94759
DAG View
PRO Name transient receptor potential cation channel subfamily M member 2 (human)
Definition A transient receptor potential cation channel subfamily M member 2 that is encoded in the genome of human.
Short Label hTRPM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94759 (TRPM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K405 Acetylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
T616 Phosphorylation PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
Y682 Phosphorylation PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
T768 Phosphorylation PhosphoSitePlus
Y863 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
T884 Phosphorylation PhosphoSitePlus
K1104 Acetylation PhosphoSitePlus
K1168 Ubiquitination PhosphoSitePlus
S1170 Phosphorylation PhosphoSitePlus
S1172 Phosphorylation PhosphoSitePlus
K1216 Ubiquitination PhosphoSitePlus
K1494 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T669 Phosphorylation HPRD 18491316
S671 Phosphorylation HPRD 18491316
Y682 Phosphorylation HPRD 18491316
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 24337049


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T616 I616 Biomuta DOID:4159 / skin cancer [ cosmic ]
T618 I618 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S671 I671 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S1170 L1170 Biomuta DOID:4159 / skin cancer [ cosmic ]