iPTMnet Report for O76083 (PDE9A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O76083 / PDE9A_HUMAN
Protein Name High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Gene Name Name: PDE9A
Organism Homo sapiens (Human)

PRO ID PR:O76083
DAG View
PRO Name high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (human)
Definition A high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A that is encoded in the genome of human.
Short Label hPDE9A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O76083 (PDE9A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y29 Phosphorylation PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
Y444 Phosphorylation PhosphoSitePlus
T508 Phosphorylation PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus
T567 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T62 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S87 C87 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y444 D444 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T571 M571 Biomuta DOID:4159 / skin cancer [ cosmic ]
S578 F578 Biomuta [ cosmic ]
S582 G582 Biomuta DOID:10534 / stomach cancer [ cosmic ]