Protein Information

Cytoscape View


UniProt AC / UniProt ID O76074 / PDE5A_HUMAN
Protein Name cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Name Name: PDE5A
Synonyms:PDE5;
Organism Homo sapiens (Human)

PRO ID PR:O76074
DAG View
PRO Name cGMP-specific 3',5'-cyclic phosphodiesterase (human)
Definition A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of human.
Short Label hPDE5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O76074 (PDE5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus   RLIMS-P 29341896, 27462268
S102 Phosphorylation P17612 (PRKACA) , Q13976 (PRKG1) phospho.ELM   PhosphoSitePlus   RLIMS-P 11723116, 16690614, 2168396, ...26093192, 12359732
S104 Phosphorylation PhosphoSitePlus
T137 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
S869 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S102 Phosphorylation Q13976 (PRKG1) HPRD 2168396
Site PTM Type PTM Enzyme Score Source PMID
S60 Phosphorylation Q13976 (PRKG1) HPRD 2168396


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S92 N92 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S102 P102 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S869 R869 Biomuta DOID:3571 / liver cancer [ icgc ]