iPTMnet Report O76074 PDE5A

Protein Information

Cytoscape View

UniProt AC / UniProt ID	O76074 / PDE5A_HUMAN
Protein Name	cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Name	Name: PDE5A Synonyms:PDE5;
Organism	Homo sapiens (Human)

PRO ID	PR:O76074 DAG View
PRO Name	cGMP-specific 3',5'-cyclic phosphodiesterase (human)
Definition	A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of human.
Short Label	hPDE5A
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O76074 (PDE5A) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S86	Phosphorylation		score1	PhosphoSitePlus
	S92	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	27462268
	S102	Phosphorylation	P17612 (PRKACA) , Q13976 (PRKG1)	score4	phospho.ELM PhosphoSitePlus RLIMS-P	11723116, 16690614, 2168396, ...26093192, 12359732
	S104	Phosphorylation		score1	PhosphoSitePlus
	T137	Phosphorylation		score1	PhosphoSitePlus
	K243	Ubiquitination		score1	PhosphoSitePlus
	K633	Ubiquitination		score1	PhosphoSitePlus
	C689	Methylation		score1	IEDB	31844290
	K714	Ubiquitination		score1	PhosphoSitePlus
	S869	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S102	Phosphorylation	Q13976 (PRKG1)	score1	HPRD	2168396

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S60	Phosphorylation	Q13976 (PRKG1)	score1	HPRD	2168396

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S60	P60	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]
S102	P102	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]