iPTMnet Report for O76064 (RNF8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O76064 / RNF8_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF8
Gene Name Name: RNF8
Synonyms:KIAA0646;
Organism Homo sapiens (Human)

PRO ID PR:O76064
DAG View
PRO Name E3 ubiquitin-protein ligase RNF8 (human)
Definition An E3 ubiquitin-protein ligase RNF8 that is encoded in the genome of human.
Short Label hRNF8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O76064 (RNF8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K67 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S157 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
K192 Ubiquitination PhosphoSitePlus
T198 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S157 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S157 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K80 N80 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K192 R192 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K206 R206 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]