Protein Information

Cytoscape View


UniProt AC / UniProt ID O76039 / CDKL5_HUMAN
Protein Name Cyclin-dependent kinase-like 5
Gene Name Name: CDKL5
Synonyms:STK9;
Organism Homo sapiens (Human)

PRO ID PR:O76039
DAG View
PRO Name cyclin-dependent kinase-like 5 (human)
Definition A cyclin-dependent kinase-like 5 that is encoded in the genome of human.
Short Label hCDKL5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O76039 (CDKL5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Acetylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K33 Acetylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
T169 Phosphorylation O76039 (CDKL5) PhosphoSitePlus 16935860
Y171 Phosphorylation O76039 (CDKL5) PhosphoSitePlus   RLIMS-P 16935860, 30266825
Y262 Phosphorylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
S407 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231, ...19369195
S446 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y482 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
T533 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
T658 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
Y704 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S726 Phosphorylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus   UniProt 18691976
T813 Phosphorylation PhosphoSitePlus
T831 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y171 Phosphorylation HPRD 18691976, 20068231
S306 Phosphorylation HPRD 18691976
S375 Phosphorylation HPRD 18691976
S377 Phosphorylation HPRD 18691976
S407 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S476 Phosphorylation HPRD 18691976
S512 Phosphorylation HPRD 19664994
S526 Phosphorylation HPRD 18691976
T528 Phosphorylation HPRD 18691976
S543 Phosphorylation HPRD 18691976
S646 Phosphorylation HPRD 18691976
S681 Phosphorylation HPRD 18691976
S720 Phosphorylation HPRD 18691976
S726 Phosphorylation HPRD 18691976
S761 Phosphorylation HPRD 18691976
T983 Phosphorylation PhosphoSitePlus
S987 Phosphorylation PhosphoSitePlus


O76039 (CDKL5) as PTM Enzyme



Substrate Site Score Source PMID
O76039 (CDKL5) T169 PhosphoSitePlus 16935860
O76039 (CDKL5) Y171 PhosphoSitePlus 16935860
P49418 (AMPH) S293 neXtProt 23651931
Q9HCJ2 (LRRC4C) S631 PhosphoSitePlus   Signor 22922712


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T528 P528 Biomuta DOID:1612 / breast cancer [ icgc ]
S681 P681 Biomuta DOID:363 / uterine cancer [ tcga ]
S726 Y726 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]