iPTMnet Report for O76021 (RSL1D1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O76021 / RL1D1_HUMAN
Protein Name Ribosomal L1 domain-containing protein 1
Gene Name Name: RSL1D1
Synonyms:CATX11,CSIG;ORFNames:L12;
Organism Homo sapiens (Human)

PRO ID PR:O76021
DAG View
PRO Name ribosomal L1 domain-containing protein 1 (human)
Definition A ribosomal L1 domain-containing protein 1 that is encoded in the genome of human.
Short Label hRSL1D1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O76021 (RSL1D1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
S6 Phosphorylation PhosphoSitePlus
T15 Phosphorylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S105 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T106 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K116 Methylation PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Methylation PhosphoSitePlus
K120 Sumoylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K124 Methylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
R160 Methylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
C197 S-Nitrosylation dbSNO 19483679
K244 Acetylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K254 Acetylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
K318 Acetylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
K337 Acetylation PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus   UniProt 17081983, 20068231
K345 Acetylation PhosphoSitePlus
T358 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16083285, 21406692, ...16565220
S361 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 16565220, 18669648, 19690332, 20068231
K373 Ubiquitination PhosphoSitePlus
T375 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K380 Acetylation PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
S392 O-Glycosylation GlyGen 33465208
S392 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 20068231, ...17081983
K395 Methylation PhosphoSitePlus
S396 O-Glycosylation GlyGen 33465208
S396 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 16964243
S400 O-Glycosylation GlyGen 30444036, 34725712, 32522876, ...33214551, 33465208, 34019948, 35083852, 32870666, 28510447, 22121020, 34229054
S400 Phosphorylation PhosphoSitePlus
T401 O-Glycosylation GlyGen 33465208
T401 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16964243
S413 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T415 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S421 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T423 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243
S427 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 16565220, 18669648, 20068231, 16964243
K435 Sumoylation PhosphoSitePlus
S443 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S445 Phosphorylation PhosphoSitePlus
K449 Methylation PhosphoSitePlus
T454 Phosphorylation PhosphoSitePlus
K461 Acetylation PhosphoSitePlus
T464 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T465 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 23186163, 16964243, ...16565220, 18669648
S467 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K468 Acetylation PhosphoSitePlus   UniProt 19608861
S469 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243
T476 Phosphorylation PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 18491316
S105 Phosphorylation HPRD 18669648
T106 Phosphorylation HPRD 20068231
S325 Phosphorylation HPRD 19007248, 19691289
T328 Phosphorylation HPRD 19007248
T340 Phosphorylation HPRD 17081983, 20068231
T358 Phosphorylation HPRD 18578522, 18491316, 18212344, ...20230923, 16565220, 20058876, 19664995, 19691289, 19651622, 18669648, 19007248, 18452278, 20068231, 17924679
S361 Phosphorylation HPRD 19413330, 17322306, 18578522, ...18491316, 20058876, 20230923, 19562805, 18767875, 19664994, 19691289, 19664995, 19651622, 18669648, 18707149, 19007248, 18452278, 19415658, 20068231, 17924679
T375 Phosphorylation HPRD 18669648, 20068231
S392 Phosphorylation HPRD 17081983, 18669648, 19007248, ...20068231, 16964243
S396 Phosphorylation HPRD 18669648, 19007248, 19691289, ...20068231, 16964243
S400 Phosphorylation HPRD 20068231
T401 Phosphorylation HPRD 18669648, 16964243, 20068231, ...19007248
S413 Phosphorylation HPRD 18669648
T415 Phosphorylation HPRD 18669648, 20068231
S421 Phosphorylation HPRD 18669648, 19007248, 20068231
T423 Phosphorylation HPRD 16964243, 19007248, 19691289, ...19651622, 18669648, 20068231
S427 Phosphorylation HPRD 19664995, 16964243, 19007248, ...16565220, 19651622, 18669648, 20068231, 19691289
S443 Phosphorylation HPRD 18669648, 17081983, 20068231, ...19007248
S445 Phosphorylation HPRD 19651622, 19007248, 20068231, ...18452278
T454 Phosphorylation HPRD 20068231
T464 Phosphorylation HPRD 18669648, 20068231
T465 Phosphorylation HPRD 19413330, 16083285, 16964243, ...16565220, 18669648, 19415658, 20068231, 17924679
S467 Phosphorylation HPRD 18669648, 20068231, 17924679
S469 Phosphorylation HPRD 18669648, 18212344, 19415658, ...20068231, 16964243


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 L6 Biomuta DOID:1612 / breast cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S6 T6 Biomuta DOID:1324 / lung cancer [ cosmic ]
T15 I15 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T45 M45 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
T45 A45 Biomuta DOID:1319 / brain cancer [ cosmic ]
S87 N87 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K100 R100 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K116 R116 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K116 E116 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S127 F127 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S141 F141 Biomuta DOID:4159 / skin cancer [ cosmic ]
S167 L167 Biomuta DOID:1612 / breast cancer [ cosmic ]
S266 P266 Biomuta DOID:3571 / liver cancer [ cosmic ]
K311 N311 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K373 R373 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K395 N395 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S400 T400 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S413 F413 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K435 R435 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S445 L445 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T464 I464 Biomuta DOID:4159 / skin cancer [ cosmic ]
T464 N464 Biomuta DOID:3571 / liver cancer [ cosmic ]
T464 A464 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S469 Y469 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T476 N476 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]