Protein Information

Cytoscape View


UniProt AC / UniProt ID O75976 / CBPD_HUMAN
Protein Name Carboxypeptidase D precursor
Gene Name Name: CPD
Organism Homo sapiens (Human)

PRO ID PR:O75976
DAG View
PRO Name carboxypeptidase D (human)
Definition A carboxypeptidase D that is encoded in the genome of human.
Short Label hCPD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75976 (CPD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus
T40 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
T41 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
T42 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
T43 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
T44 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
S45 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
N172 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 12754519, ...24190977
S203 Phosphorylation PhosphoSitePlus
T226 O-Glycosylation GlyGen 30459171
K281 Ubiquitination PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
N399 N-Glycosylation GlyGen 24190977
N408 N-Glycosylation GlyGen 24190977
N410 N-Glycosylation GlyGen 24190977
T489 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
Y520 Phosphorylation PhosphoSitePlus
N522 N-Glycosylation GlyGen 23090970, 29741879, 24190977
Y527 Phosphorylation PhosphoSitePlus
S528 O-Glycosylation GlyGen 29351928
K531 Ubiquitination PhosphoSitePlus
S532 O-Glycosylation GlyGen 29351928
S532 Phosphorylation PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
Y611 Phosphorylation PhosphoSitePlus
N626 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N711 N-Glycosylation GlyGen 24190977
N811 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 12754519, ...19159218, 24190977
K841 Methylation PhosphoSitePlus
N855 N-Glycosylation GlyGen 24190977
N867 N-Glycosylation GlyGen 23090970, 29741879, 24190977
S895 Phosphorylation PhosphoSitePlus
T898 Phosphorylation PhosphoSitePlus
T899 Phosphorylation PhosphoSitePlus
K900 Ubiquitination PhosphoSitePlus
T904 Phosphorylation PhosphoSitePlus
S910 Phosphorylation PhosphoSitePlus
N949 N-Glycosylation GlyGen 24190977
N955 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 12754519, ...19159218, 24190977
N958 N-Glycosylation GlyGen 24190977
N978 N-Glycosylation GlyGen 24190977
R1027 Methylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus
T1050 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus
T1056 Phosphorylation PhosphoSitePlus
N1069 N-Glycosylation GlyGen 24190977
N1070 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
N1142 N-Glycosylation GlyGen 24190977
N1147 N-Glycosylation GlyGen 24190977
K1220 Ubiquitination PhosphoSitePlus
S1324 Phosphorylation PhosphoSitePlus
K1331 Ubiquitination PhosphoSitePlus
Y1344 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S1352 Phosphorylation PhosphoSitePlus
S1355 Phosphorylation PhosphoSitePlus
K1357 Ubiquitination PhosphoSitePlus
S1358 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332
S1361 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 19690332
T1368 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
T1370 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
T1374 Phosphorylation PhosphoSitePlus
Y1376 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S1377 Phosphorylation PhosphoSitePlus
S1378 Phosphorylation PhosphoSitePlus
K1379 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y1344 Phosphorylation HPRD 18083107
S1358 Phosphorylation HPRD 20068231
S1361 Phosphorylation HPRD 18669648, 20068231
T1368 Phosphorylation HPRD 19651622, 18669648, 20068231
T1370 Phosphorylation HPRD 19651622, 18669648, 20068231
Y1376 Phosphorylation HPRD 18083107


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P20963 (CD247) Y72 O75976 (CPD) unknown eFIP 24502978


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T43 A43 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S283 L283 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S283 * Biomuta DOID:1612 / breast cancer [ icgc ]
S528 F528 Biomuta DOID:1909 / melanoma [ tcga ]
N711 K711 Biomuta DOID:363 / uterine cancer [ cosmic ]
S910 L910 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ tcga ]
S910 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1051 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
Y1344 C1344 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1361 I1361 Biomuta DOID:3571 / liver cancer [ icgc ]
T1368 A1368 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y1376 C1376 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S1377 Y1377 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]