iPTMnet Report for O75969 (AKAP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75969 / AKAP3_HUMAN
Protein Name A-kinase anchor protein 3
Gene Name Name: AKAP3
Synonyms:AKAP110,SOB1;
Organism Homo sapiens (Human)

PRO ID PR:O75969
DAG View
PRO Name A-kinase anchor protein 3 (human)
Definition An A-kinase anchor protein 3 that is encoded in the genome of human.
Short Label hAKAP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75969 (AKAP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T34 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus   UniProt 12509440
S206 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus   UniProt 12509440
Y214 Phosphorylation PhosphoSitePlus
K225 Acetylation PhosphoSitePlus
K237 Acetylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus   UniProt 12509440
Y404 Phosphorylation PhosphoSitePlus   UniProt 12509440
T428 Phosphorylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus   UniProt 12509440
S636 Phosphorylation PhosphoSitePlus   UniProt 12509440


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S35 Y35 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T36 M36 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
T102 A102 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K237 N237 Biomuta DOID:363 / uterine cancer [ icgc ]
Y404 N404 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K433 N433 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S440 L440 Biomuta DOID:4159 / skin cancer [ cosmic ]
S440 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S612 R612 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S635 F635 Biomuta DOID:1319 / brain cancer [ icgc ]