iPTMnet Report for O75962 (TRIO)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75962 / TRIO_HUMAN
Protein Name Triple functional domain protein
Gene Name Name: TRIO
Organism Homo sapiens (Human)

PRO ID PR:O75962
DAG View
PRO Name triple functional domain protein (human)
Definition A triple functional domain protein that is encoded in the genome of human.
Short Label hTRIO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75962 (TRIO) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T89 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K265 Acetylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
K681 Acetylation PhosphoSitePlus
T724 Phosphorylation PhosphoSitePlus
K1131 Ubiquitination PhosphoSitePlus
C1220 Methylation IEDB 31844290
Y1228 Phosphorylation PhosphoSitePlus
S1258 Phosphorylation PhosphoSitePlus
S1459 Phosphorylation PhosphoSitePlus
T1545 Phosphorylation PhosphoSitePlus
S1627 Phosphorylation PhosphoSitePlus
S1632 Phosphorylation PhosphoSitePlus
S1633 Phosphorylation PhosphoSitePlus
S1645 Phosphorylation PhosphoSitePlus
S1655 Phosphorylation PhosphoSitePlus
T1700 Phosphorylation PhosphoSitePlus
S1704 Phosphorylation PhosphoSitePlus
S1723 Phosphorylation PhosphoSitePlus
S1724 Phosphorylation PhosphoSitePlus
S1745 Phosphorylation PhosphoSitePlus
S1749 Phosphorylation PhosphoSitePlus
S1752 Phosphorylation PhosphoSitePlus
T1778 Phosphorylation PhosphoSitePlus
S1779 Phosphorylation PhosphoSitePlus
S1785 Phosphorylation PhosphoSitePlus
S1786 Phosphorylation PhosphoSitePlus
K1808 Acetylation PhosphoSitePlus
S1809 Phosphorylation PhosphoSitePlus
S1814 Phosphorylation PhosphoSitePlus
S1818 Phosphorylation PhosphoSitePlus
S1821 Phosphorylation PhosphoSitePlus
T1824 Phosphorylation PhosphoSitePlus
T1843 Phosphorylation PhosphoSitePlus
S1845 Phosphorylation PhosphoSitePlus
S1847 Phosphorylation PhosphoSitePlus
S1854 Phosphorylation PhosphoSitePlus
T1899 Phosphorylation PhosphoSitePlus
S1900 Phosphorylation PhosphoSitePlus
S1901 Phosphorylation PhosphoSitePlus
T1903 Phosphorylation PhosphoSitePlus
Y2058 Phosphorylation PhosphoSitePlus
Y2075 Phosphorylation PhosphoSitePlus
K2120 Ubiquitination PhosphoSitePlus
S2122 Phosphorylation PhosphoSitePlus
S2208 Phosphorylation PhosphoSitePlus
S2255 Phosphorylation PhosphoSitePlus
S2282 Phosphorylation PhosphoSitePlus   UniProt 18669648
Y2286 Phosphorylation PhosphoSitePlus
S2302 Phosphorylation PhosphoSitePlus
S2326 Phosphorylation PhosphoSitePlus
S2358 Phosphorylation PhosphoSitePlus
S2388 Phosphorylation PhosphoSitePlus
S2391 Phosphorylation PhosphoSitePlus
S2402 Phosphorylation PhosphoSitePlus
S2417 Phosphorylation PhosphoSitePlus
S2428 Phosphorylation PhosphoSitePlus
S2429 Phosphorylation PhosphoSitePlus
S2440 Phosphorylation PhosphoSitePlus
T2443 Phosphorylation PhosphoSitePlus
S2455 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S2459 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S2462 Phosphorylation PhosphoSitePlus
S2467 Phosphorylation PhosphoSitePlus
S2476 Phosphorylation PhosphoSitePlus
S2477 Phosphorylation PhosphoSitePlus
K2481 Acetylation PhosphoSitePlus
S2492 Phosphorylation PhosphoSitePlus
S2495 Phosphorylation PhosphoSitePlus
S2506 Phosphorylation PhosphoSitePlus
S2508 Phosphorylation PhosphoSitePlus
T2513 Phosphorylation PhosphoSitePlus
T2625 Phosphorylation PhosphoSitePlus
S2631 Phosphorylation PhosphoSitePlus   UniProt 23186163
T2634 Phosphorylation PhosphoSitePlus
K2640 Acetylation PhosphoSitePlus
Y2659 Phosphorylation PhosphoSitePlus
S2671 Phosphorylation PhosphoSitePlus
S2794 Phosphorylation PhosphoSitePlus
Y2796 Phosphorylation PhosphoSitePlus 12551902
Y2796 Phosphorylation Q05397 (PTK2) PhosphoSitePlus 12551902
R2804 Methylation PhosphoSitePlus
C2880 Methylation IEDB 31844290
S3068 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1779 Phosphorylation HPRD 19664994
T1903 Phosphorylation HPRD 17081983
T2281 Phosphorylation HPRD 20068231
S2282 Phosphorylation HPRD 18669648
S2417 Phosphorylation HPRD 19664994
S2429 Phosphorylation HPRD 19651622
S2440 Phosphorylation HPRD 20068231
S2455 Phosphorylation HPRD 19413330, 18767875, 20058876, ...19651622, 18669648, 20068231
S2459 Phosphorylation HPRD 19413330, 18767875, 19651622, ...20068231
S2462 Phosphorylation HPRD 19651622
S2467 Phosphorylation HPRD 18669648
Y2796 Phosphorylation HPRD 12551902
Y2796 Phosphorylation Q05397 (PTK2) HPRD 12551902


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T89 A89 Biomuta DOID:1319 / brain cancer [ cosmic ]
T89 M89 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S297 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1545 S1545 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1545 I1545 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1704 F1704 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1704 C1704 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1749 F1749 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1785 I1785 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1814 L1814 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S1847 A1847 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1903 K1903 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y2075 C2075 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2120 N2120 Biomuta DOID:263 / kidney cancer [ cosmic ]
S2122 I2122 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2282 L2282 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S2402 F2402 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2428 L2428 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2455 L2455 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2462 C2462 Biomuta DOID:363 / uterine cancer [ icgc ]
S2492 P2492 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S2508 F2508 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2631 F2631 Biomuta DOID:1324 / lung cancer [ cosmic ]
T2634 I2634 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2671 Y2671 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
S2794 F2794 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y2796 C2796 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S3068 F3068 Biomuta DOID:4159 / skin cancer [ cosmic ]