iPTMnet Report for O75937 (DNAJC8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75937 / DNJC8_HUMAN
Protein Name DnaJ homolog subfamily C member 8
Gene Name Name: DNAJC8
Synonyms:SPF31;ORFNames:HSPC315,HSPC331;
Organism Homo sapiens (Human)

PRO ID PR:O75937
DAG View
PRO Name DnaJ homolog subfamily C member 8 (human)
Definition A DnaJ homolog subfamily C member 8 that is encoded in the genome of human.
Short Label hDNAJC8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75937 (DNAJC8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
Y24 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S35 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K40 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
R118 Methylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K146 Acetylation PhosphoSitePlus   UniProt 19608861
K146 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
S215 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S222 Phosphorylation PhosphoSitePlus   UniProt 23186163
R224 Methylation PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
R239 Methylation PhosphoSitePlus
R243 Methylation PhosphoSitePlus
K248 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K75 T75 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K88 T88 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S215 R215 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S222 I222 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R224 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K231 N231 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]