iPTMnet Report for O75925 (PIAS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75925 / PIAS1_HUMAN
Protein Name E3 SUMO-protein ligase PIAS1
Gene Name Name: PIAS1
Synonyms:DDXBP1;
Organism Homo sapiens (Human)

PRO ID PR:O75925
DAG View
PRO Name E3 SUMO-protein ligase PIAS1 (human)
Definition An E3 SUMO-protein ligase PIAS1 that is encoded in the genome of human.
Short Label hPIAS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75925 (PIAS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S4 Phosphorylation PhosphoSitePlus
K8 Sumoylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus 26157031
S17 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 26157031
K30 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K40 Sumoylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K46 Sumoylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
K56 Sumoylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K58 Sumoylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
S90 Phosphorylation RLIMS-P 24894488, 24586797, 17540171
K117 Sumoylation PhosphoSitePlus
K137 Sumoylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K152 Sumoylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
C228 Methylation IEDB 31844290
K238 Sumoylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
R303 Methylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K315 Sumoylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
S466 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 19217413, 17081983
S466 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 19217413
S467 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 19217413, 17081983, 24275569
S467 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 19217413
S468 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 19217413, 17081983, 24275569
S468 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 19217413
S476 Phosphorylation PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
S483 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S485 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 21676946
T487 Phosphorylation PhosphoSitePlus
S488 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K493 Ubiquitination PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S503 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...19690332, 20068231
S506 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T508 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus   Signor   UniProt 27256105, 19690332
S510 Phosphorylation Q13131 (PRKAA1) Signor 27256105
S522 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23202365, 18669648
S522 Phosphorylation P49137 (MAPKAPK2) neXtProt   PhosphoSitePlus   Signor 23202365
Site PTM Type PTM Enzyme Score Source PMID
S90 Phosphorylation HPRD 17540171
S90 Phosphorylation O15111 (CHUK) HPRD 17540171
S466 Phosphorylation HPRD 19651622, 17081983
S467 Phosphorylation HPRD 19651622, 17081983
S468 Phosphorylation HPRD 19651622, 17081983
S485 Phosphorylation HPRD 18669648, 17081983
T487 Phosphorylation HPRD 17081983, 20068231
S488 Phosphorylation HPRD 18669648, 17081983
S503 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231, 18452278
S506 Phosphorylation HPRD 18669648, 20068231
S522 Phosphorylation HPRD 18669648
T635 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42224 (STAT1) S727 O75925 (PIAS1) increased_association eFIP 17897103
Phosphorylation Q01826 (SATB1) T188 O75925 (PIAS1) unknown eFIP 20351170


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 T8 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T71 M71 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K226 T226 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S308 F308 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T327 P327 Biomuta DOID:4362 / cervical cancer [ icgc ]
K420 R420 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S510 R510 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T635 R635 Biomuta DOID:2394 / ovarian cancer [ cosmic ]