iPTMnet Report for O75891 (ALDH1L1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75891 / AL1L1_HUMAN
Protein Name Cytosolic 10-formyltetrahydrofolate dehydrogenase
Gene Name Name: ALDH1L1
Synonyms:FTHFD;
Organism Homo sapiens (Human)

PRO ID PR:O75891
DAG View
PRO Name cytosolic 10-formyltetrahydrofolate dehydrogenase (human)
Definition A 10-formyltetrahydrofolate dehydrogenase that is encoded in the genome of human.
Short Label hALDH1L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75891 (ALDH1L1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus   UniProt 24275569
K35 Acetylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
R112 Methylation PhosphoSitePlus
K187 Methylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus   UniProt 24275569
S631 Phosphorylation PhosphoSitePlus   UniProt 24275569
K660 Acetylation PhosphoSitePlus
C662 Methylation IEDB 31844290
C662 S-Nitrosylation dbSNO 24105792
K668 Acetylation PhosphoSitePlus
C686 Methylation IEDB 31844290
S825 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y848 Phosphorylation PhosphoSitePlus
K876 Acetylation PhosphoSitePlus
K882 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T613 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S405 R405 Biomuta DOID:1324 / lung cancer [ cosmic ]
S405 I405 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T613 A613 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S629 F629 Biomuta DOID:363 / uterine cancer [ icgc ]
S631 C631 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S631 F631 Biomuta DOID:4159 / skin cancer [ cosmic ]
K876 I876 Biomuta DOID:10534 / stomach cancer [ cosmic ]