Protein Information

Cytoscape View

UniProt AC / UniProt ID O75886 / STAM2_HUMAN
Protein Name Signal transducing adapter molecule 2
Gene Name Name: STAM2
Organism Homo sapiens (Human)

PRO ID PR:O75886
DAG View
PRO Name signal transducing adapter molecule 2 (human)
Definition A signal transducing adapter molecule 2 that is encoded in the genome of human.
Short Label hSTAM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O75886 (STAM2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K57 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
Y192 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18626516, 10993906, 17081983, ...11687594
K202 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus   RLIMS-P 18626516
Y291 Phosphorylation P06241 (FYN) PhosphoSitePlus 18626516
K296 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
Y371 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18626516, 15592455, 15144186
Y371 Phosphorylation P06241 (FYN) PhosphoSitePlus 18626516
S372 Phosphorylation PhosphoSitePlus
Y374 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 15592455, 18626516, 15144186
Y374 Phosphorylation P06241 (FYN) PhosphoSitePlus 18626516
S375 Phosphorylation PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y192 Phosphorylation HPRD 19901323, 17389395, 10993906, ...11687594
Y192 Phosphorylation P00533 (EGFR) HPRD 19901323, 17389395, 10993906, ...11687594
Y291 Phosphorylation HPRD 17389395
Y371 Phosphorylation HPRD 15144186
S372 Phosphorylation HPRD 15144186
Y374 Phosphorylation HPRD 19901323, 15144186


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049362 (hSTAM2/UbiqLys+) ub PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K57 * Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
K57 R57 Biomuta DOID:1324 / lung cancer [ cosmic ]
K172 T172 Biomuta DOID:363 / uterine cancer [ tcga ]
K189 E189 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K283 N283 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K296 N296 Biomuta DOID:1324 / lung cancer [ tcga ]
S375 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]