Protein Information

Cytoscape View


UniProt AC / UniProt ID O75874 / IDHC_HUMAN
Protein Name Isocitrate dehydrogenase [NADP] cytoplasmic
Gene Name Name: IDH1
Synonyms:PICD;
Organism Homo sapiens (Human)

PRO ID PR:O75874
DAG View
PRO Name isocitrate dehydrogenase [NADP] cytoplasmic (human)
Definition An isocitrate dehydrogenase [NADP] cytoplasmic that is encoded in the genome of human.
Short Label hIDH1nadp
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75874 (IDH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
T19 Phosphorylation HPRD   PhosphoSitePlus 20068231
K29 Acetylation PhosphoSitePlus
Y34 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 30862724, 24275569
K58 Acetylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
C73 S-Nitrosylation dbSNO 24105792
T75 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Methylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
C114 S-Nitrosylation dbSNO 24105792
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
K151 Acetylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
T214 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y219 Phosphorylation HPRD   PhosphoSitePlus 20068231
K224 Acetylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
K233 Acetylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K243 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
K321 Acetylation PhosphoSitePlus   UniProt 19608861
K321 Ubiquitination PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
K345 Acetylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
C379 S-Nitrosylation dbSNO 24105792
K381 Ubiquitination PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
Y391 Phosphorylation PhosphoSitePlus   RLIMS-P 30862724
K400 Acetylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y34 * Biomuta DOID:3571 / liver cancer [ icgc ]
K81 N81 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S94 * Biomuta DOID:1909 / melanoma [ cosmic ]
T98 N98 Biomuta DOID:3571 / liver cancer [ icgc ]
T106 M106 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K126 R126 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K151 N151 Biomuta DOID:1612 / breast cancer [ tcga ]
T162 A162 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y208 C208 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T325 M325 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
C379 G379 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]