Protein Information

Cytoscape View


UniProt AC / UniProt ID O75844 / FACE1_HUMAN
Protein Name CAAX prenyl protease 1 homolog
Gene Name Name: ZMPSTE24
Synonyms:FACE1,STE24;
Organism Homo sapiens (Human)

PRO ID PR:O75844
DAG View
PRO Name CAAX prenyl protease 1 homolog (human)
Definition A CAAX prenyl protease 1 that is encoded in the genome of human.
Short Label hZMPSTE24
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75844 (ZMPSTE24) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
T250 Phosphorylation HPRD   PhosphoSitePlus 18452278
K251 Ubiquitination PhosphoSitePlus
Y253 Phosphorylation HPRD   PhosphoSitePlus 18452278
K259 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S310 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K314 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K429 Acetylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 * Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S6 L6 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
S6 W6 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
K46 T46 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K66 E66 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S67 F67 Biomuta DOID:3571 / liver cancer [ icgc ]
K233 N233 Biomuta DOID:3571 / liver cancer [ icgc ]
K316 E316 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]