iPTMnet Report O75844 ZMPSTE24

Protein Information

UniProt AC / UniProt ID	O75844 / FACE1_HUMAN
Protein Name	CAAX prenyl protease 1 homolog
Gene Name	Name: ZMPSTE24 Synonyms:FACE1;
Organism	Homo sapiens (Human)

PRO ID	PR:O75844 DAG View
PRO Name	CAAX prenyl protease 1 homolog (human)
Definition	A CAAX prenyl protease 1 that is encoded in the genome of human.
Short Label	hZMPSTE24
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O75844 (ZMPSTE24) as Substrate

O75844

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S6 T35 Y45 K46 S61 K66 S67 K233 K235 K243 S244 T250 K251 Y253 K259 K292 S298 S310 K314 K316 K325 K341 K427 K429 Y432 S433 K437 K470	PTM Type Select all Acetylation Phosphorylation Ubiquitination	Score Select all 1 2	Source Select all HPRD PhosphoSitePlus phospho.ELM	PMID
S6	Phosphorylation	score1	PhosphoSitePlus
T35	Phosphorylation	score1	PhosphoSitePlus
Y45	Phosphorylation	score1	PhosphoSitePlus
K46	Ubiquitination	score1	PhosphoSitePlus
S61	Phosphorylation	score1	PhosphoSitePlus
K66	Ubiquitination	score1	PhosphoSitePlus
S67	Phosphorylation	score1	PhosphoSitePlus
K233	Ubiquitination	score1	PhosphoSitePlus
K235	Ubiquitination	score1	PhosphoSitePlus
K243	Ubiquitination	score1	PhosphoSitePlus
S244	Phosphorylation	score1	PhosphoSitePlus
T250	Phosphorylation	score2	HPRD PhosphoSitePlus	18452278
K251	Ubiquitination	score1	PhosphoSitePlus
Y253	Phosphorylation	score2	HPRD PhosphoSitePlus	18452278
K259	Ubiquitination	score1	PhosphoSitePlus
K292	Ubiquitination	score1	PhosphoSitePlus
S298	Phosphorylation	score1	PhosphoSitePlus
S310	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus	18669648
K314	Ubiquitination	score1	PhosphoSitePlus
K316	Ubiquitination	score1	PhosphoSitePlus
K325	Ubiquitination	score1	PhosphoSitePlus
K341	Ubiquitination	score1	PhosphoSitePlus
K427	Acetylation	score1	PhosphoSitePlus
K429	Acetylation	score1	PhosphoSitePlus
K429	Ubiquitination	score1	PhosphoSitePlus
Y432	Phosphorylation	score1	PhosphoSitePlus
S433	Phosphorylation	score1	PhosphoSitePlus
K437	Ubiquitination	score1	PhosphoSitePlus
K470	Ubiquitination	score1	PhosphoSitePlus

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S6 T35 K46 K66 K316	Variant Select all * A35 E316 E66 L6 T46 W6	Source Select all Biomuta	Disease [Sample source] Select all DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ icgc ]
S6	*	Biomuta	DOID:4362 / cervical cancer [ cosmic ]
S6	L6	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
S6	W6	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T35	A35	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K46	T46	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
K66	E66	Biomuta	DOID:9256 / colorectal cancer [ icgc ]
K316	E316	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O75844 (ZMPSTE24)

Protein Information

Interactive Sequence View

O75844 (ZMPSTE24) as Substrate

PTM sites affected in variants